1-(2-CHLOROETHYL)-PYRROLIDINE

Base Information

• Chemical Name: 1-(2-CHLOROETHYL)-PYRROLIDINE
• CAS No.: 5050-41-9
• Molecular Formula: C6H12ClN
• Molecular Weight: 133.621
• Hs Code.: 2933990090
• Mol file: 5050-41-9.mol

Synonyms:Pyrrolidine, 1-(2-chloroethyl)-;N-(2-chloroethyl)pyrrolidine;1-(2-Chloro-ethyl)-pyrrolidine hydrochloride;

Chemical Property of 1-(2-CHLOROETHYL)-PYRROLIDINE

Chemical Property:

• Boiling Point: 170.5 °C at 760 mmHg
• PKA: 9.37±0.20(Predicted)
• Flash Point: 56.9 °C
• PSA: 3.24000
• Density: 1.037 g/cm³
• LogP: 1.25890
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-(2-chloroethyl)pyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: 1-(2-Chloroethyl)-pyrrolidine, a chemical compound, has various applications in different fields. In the pharmaceutical industry, it serves as an important intermediate in the synthesis of pharmaceutical compounds, particularly those used in the development of medications with potential therapeutic properties. Its role is pivotal in the structural modification of molecules, enabling the creation of novel drug candidates for various medical conditions. Additionally, in academic research and organic chemistry, this compound can be employed as a building block for the synthesis of complex organic molecules, facilitating studies in chemical synthesis and the exploration of new chemical reactions and methodologies. Its versatility across these fields underscores its significance in drug discovery, academic research, and the advancement of chemical science, ultimately contributing to the improvement of healthcare and scientific knowledge.

Technology Process of 1-(2-CHLOROETHYL)-PYRROLIDINE

There total 3 articles about 1-(2-CHLOROETHYL)-PYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.26%

→ N-(2-chloroethyl)-pyrrolidine (5050-41-9)

Guidance literature:

With thionyl chloride; In toluene; at 25 ℃; for 12h;

Reference yield: 63.0%

1-(2-chloroethyl)pyrrolidine hydrochloride (7250-67-1) → N-(2-chloroethyl)-pyrrolidine (5050-41-9)

Guidance literature:

With potassium carbonate; In water;

Reference yield: 25.86%

1-pyrrolidineethanol (2955-88-6) → N-(2-chloroethyl)-pyrrolidine (5050-41-9)

Guidance literature:

With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; at 0 - 40 ℃;

upstream raw materials:

1-pyrrolidineethanol

1-(2-chloroethyl)pyrrolidine hydrochloride

Downstream raw materials:

2-phenyl-2-[2]pyridyl-4-pyrrolidino-butyronitrile

1-(2-phenyl-4-pyrrolidino-butyryl)-piperidine

1-(3,3-diphenylpropyl)pyrrolidine

2,2-diphenyl-4-pyrrolidino-butyronitrile

Refernces

• 1、 -. "C-3 NOVEL TRITERPENONE WITH C-17 REVERSE AMIDE DERIVATIVES AS HIV INHIBITORS". Page/Page column 62. . Retrieved 2018/03/06.
• 2、 -. "Isoflavone amide type derivative, preparation method and medical application thereof". Paragraph 0016; 0080; 0081; 0082; 0083; 0084; 0085. . Retrieved 2016/10/10.