(S)-3-hydroxy-N-methyl,N-propargylphenylpropylamine

Base Information

• Chemical Name: (S)-3-hydroxy-N-methyl,N-propargylphenylpropylamine
• CAS No.: 209546-19-0
• Molecular Formula: C₁₃H₁₇NO
• Molecular Weight: 203.284
• Mol file: 209546-19-0.mol

Synonyms:(S)-3-hydroxy-N-methyl,N-propargylphenylpropylamine

Chemical Property of (S)-3-hydroxy-N-methyl,N-propargylphenylpropylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-hydroxy-N-methyl,N-propargylphenylpropylamine

There total 2 articles about (S)-3-hydroxy-N-methyl,N-propargylphenylpropylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.2%

propargyl bromide (106-96-7) + 3-[(2S)-2-(methylamino)propyl]phenol (339986-99-1) → (S)-3-hydroxy-N-methyl,N-propargylphenylpropylamine (209546-19-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl acetamide; at 25 ℃; for 24h;

DOI:10.1021/jm020120c

Reference yield:

(S)-3-(2-aminopropyl)phenol (18840-47-6) → (S)-3-hydroxy-N-methyl,N-propargylphenylpropylamine (209546-19-0)

Guidance literature:

Multi-step reaction with 3 steps

1: Heating

2: LAH / tetrahydrofuran / 5 - 20 °C

3: 90.2 percent / K₂CO₃ / N,N-dimethyl-acetamide / 24 h / 25 °C

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl acetamide;

DOI:10.1021/jm020120c

Reference yield: 84.5%

N-methyl-N-cyclohexylaminocarbonyl chloride (35028-38-7) + (S)-3-hydroxy-N-methyl,N-propargylphenylpropylamine (209546-19-0) → Cyclohexyl-methyl-carbamic acid 3-[(S)-2-(methyl-prop-2-ynyl-amino)-propyl]-phenyl ester

Guidance literature:

With sodium hydride; In acetonitrile; at 20 ℃; for 18h;

DOI:10.1021/jm020120c

upstream raw materials:

propargyl bromide

3-[(2S)-2-(methylamino)propyl]phenol

(S)-3-(2-aminopropyl)phenol

Refernces