2,3,5,6-Tetrafluorobenzoic acid

Base Information

• Chemical Name: 2,3,5,6-Tetrafluorobenzoic acid
• CAS No.: 652-18-6
• Molecular Formula: C7H2F4O2
• Molecular Weight: 194.085
• Hs Code.: 29163990
• Mol file: 652-18-6.mol

Synonyms:2,3,5,6-Tetrafluorobenzoicacid;

Chemical Property of 2,3,5,6-Tetrafluorobenzoic acid

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.0427mmHg at 25°C
• Melting Point: 150-152 °C(lit.)
• Boiling Point: 227.9 °C at 760 mmHg
• PKA: 1.66±0.10(Predicted)
• Flash Point: 91.6 °C
• PSA: 37.30000
• Density: 1.633 g/cm³
• LogP: 1.94120
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2,3,5,6-Tetrafluorobenzoic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,C
• Statements: 38-41
• Safety Statements: 22-26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2,3,5,6-Tetrafluorobenzoic Acid is a useful research chemical.

Technology Process of 2,3,5,6-Tetrafluorobenzoic acid

There total 21 articles about 2,3,5,6-Tetrafluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-chloro 2,3,5,6-tetrafluoro benzoic acid (5211-45-0) → 2,3,5,6-tetrafluorobenzoic acid (652-18-6)

Guidance literature:

With ammonium hydroxide; zinc; at 20 ℃; for 4h;

DOI:10.1016/S0022-1139(99)00082-2

Reference yield: 93.0%

Pentafluorobenzoic acid (602-94-8) → 2,3,5,6-tetrafluorobenzoic acid (652-18-6)

Guidance literature:

With zinc; In ammonium hydroxide; for 5h; Ambient temperature;

DOI:10.1016/S0040-4039(97)00730-2

Reference yield: 93.0%

carbon dioxide (124-38-9,18923-20-1) + 1,2,4,5-Tetrafluorobenzene (327-54-8) → 2,3,5,6-tetrafluorobenzoic acid (652-18-6)

Guidance literature:

carbon dioxide; 1,2,4,5-Tetrafluorobenzene; With cesium hydroxide; (hydroxido){N,N'-bis(2,6-diisopropylphenyl)imidazol-2-ylidene}copper(I); In tetrahydrofuran; at 65 ℃; for 8h; Inert atmosphere;

With hydrogenchloride; In water; Inert atmosphere;

DOI:10.1002/anie.201004153

upstream raw materials:

carbon dioxide

bis(pentafluorophenyl)ytterbium(II)

Pentafluorobenzoic acid

1,2,4,5-tetrafluoro-3-(trifluoromethyl)benzene

Downstream raw materials:

3-(bromomethyl)-1,2,4,5-tetrafluorobenzene

1,2,4,5-Tetrafluorobenzene

2,3,5,6-tetrafluorobenzoic acid chloride

methyl 2,3,5,6-tetrafluorobenzoate

Refernces

• 1、 Drakesmith, F. G.. "". . . Retrieved 1972.
• 2、 Wang, Chang-Cheng,Zhang, Guo-Xiang,Zuo, Zhi-Wei,Zeng, Rong,Zhai, Dan-Dan,Liu, Feng,Shi, Zhang-Jie. "Photo-induced deep aerobic oxidation of alkyl aromatics". . p. 1487 - 1492. Retrieved 2021/07/10.
• 3、 -. "Preparation method of 2, 3, 5, 6-tetrafluorobenzoic acid". Paragraph 0036; 0037; 0038; 0039; 0040; 0041; 0042; 0043. . Retrieved 2018/03/24.