3-n-butoxybenzonitrile

Base Information

• Chemical Name: 3-n-butoxybenzonitrile
• CAS No.: 92367-52-7
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.23
• Mol file: 92367-52-7.mol

Synonyms:3-n-butoxybenzonitrile

Chemical Property of 3-n-butoxybenzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-n-butoxybenzonitrile

There total 7 articles about 3-n-butoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-cyanobromobenzene (6952-59-6) + butan-1-ol (71-36-3) → 3-n-butoxybenzonitrile (92367-52-7)

Guidance literature:

With (4,4′-di-tert-butyl-2,2′-dipyridyl)Ni(o-tolyl)(Br); 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; at 80 ℃; for 12h; Inert atmosphere; Sealed tube; UV-irradiation;

DOI:10.1002/anie.202003359

Reference yield: 88.0%

3-iodobenzonitrile (69113-59-3) + butan-1-ol (71-36-3) → 3-n-butoxybenzonitrile (92367-52-7)

Guidance literature:

With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; In toluene; at 110 ℃; for 28h;

DOI:10.1021/ol025548k

Reference yield: 87.0%

5-methyl-1,10-phenanthroline (3002-78-6) + 3-iodobenzonitrile (69113-59-3) + butan-1-ol (71-36-3) → 3-n-butoxybenzonitrile (92367-52-7)

Guidance literature:

With CuI; caesium carbonate; In toluene;

upstream raw materials:

NU 1038

1-bromo-butane

m-cyanophenol

3-iodobenzonitrile

Downstream raw materials:

3-butoxy-benzylamine

N-(3-Butoxy-benzyl)-formamide

Refernces

• 1、 Cao, Rui,Lai, Chu-Hui,Li, Gang,Liu, Fengyi,Lu, Huan-Huan,Wang, Chao,Xiao, Jianliang,Xue, Dong,Yang, Liu,Zhang, Wei. "Light-Promoted Nickel Catalysis: Etherification of Aryl Electrophiles with Alcohols Catalyzed by a NiII-Aryl Complex". supporting information. p. 12714 - 12719. Retrieved 2020/06/02.
• 2、 Freudenreich, Charles,Samama, Jean-Pierre,Biellmann, Jean-Francois. "Design of Inhibitors from the Three-Dimensional Structure of Alcohol Dehydrogenase. Chemical Synthesis and Enzymatic Properties". . p. 3344 - 3353. Retrieved 2007/10/02.