Technology Process of tert-butyl methyl{3-[(trifluoroacetyl)amino]phenyl}carbamate
There total 5 articles about tert-butyl methyl{3-[(trifluoroacetyl)amino]phenyl}carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(3-amino-phenyl)-methyl-carbamic acid tert-butyl ester; trifluoroacetic anhydride;
In
tetrahydrofuran;
at 0 ℃;
for 0.666667h;
With
sodium hydrogencarbonate;
In
tetrahydrofuran; water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: tert-butyl alcohol / 20 h / 60 °C
2: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C
3: hydrogen / palladium 10% on activated carbon / methanol / 19 h / 20 °C
4: tetrahydrofuran / 0.67 h / 0 °C
With
hydrogen; caesium carbonate;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: tert-butyl alcohol / 20 h / 60 °C
2: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C
3: hydrogen / palladium 10% on activated carbon / methanol / 19 h / 20 °C
4: tetrahydrofuran / 0.67 h / 0 °C
With
hydrogen; caesium carbonate;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; tert-butyl alcohol;