Technology Process of C46H48N8O6
There total 10 articles about C46H48N8O6 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
20% palladium hydroxide on charcoal;
In
ethanol;
at 20 ℃;
for 7h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / -20 °C
1.2: -20 - 20 °C
1.3: 2 h / 50 °C
2.1: copper(l) iodide; hydrogen; triethylamine / trans-bis(triphenylphosphine)palladium dichloride / acetonitrile / 2 h / 85 °C / Inert atmosphere
3.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C
4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C
5.1: hydrogen / 20% palladium hydroxide on charcoal / ethanol / 7 h / 20 °C
With
hydrogenchloride; copper(l) iodide; hydrogen; chloroformic acid ethyl ester; triethylamine; N-ethyl-N,N-diisopropylamine; HATU;
trans-bis(triphenylphosphine)palladium dichloride; 20% palladium hydroxide on charcoal;
In
tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: copper(l) iodide; triethylamine / trans-bis(triphenylphosphine)palladium dichloride / 6 h / 80 °C / Inert atmosphere
2: methanol; potassium carbonate / 3 h / 20 °C
3: copper(l) iodide; hydrogen; triethylamine / trans-bis(triphenylphosphine)palladium dichloride / acetonitrile / 2 h / 85 °C / Inert atmosphere
4: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C
5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C
6: hydrogen / 20% palladium hydroxide on charcoal / ethanol / 7 h / 20 °C
With
hydrogenchloride; methanol; copper(l) iodide; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU;
trans-bis(triphenylphosphine)palladium dichloride; 20% palladium hydroxide on charcoal;
In
1,4-dioxane; ethanol; N,N-dimethyl-formamide; acetonitrile;