Technology Process of (R)-3-(1-phenylethyl)pyridine
There total 3 articles about (R)-3-(1-phenylethyl)pyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tris(2,2'-bipyridyl)ruthenium dichloride; D-glucose; glucose dehydrogenase-105; Gluconobacter Oxydans ene reductase; nicotinamide adenine dinucleotide phosphate;
In
isopropyl alcohol;
at 4 ℃;
for 48h;
pH=9;
enantioselective reaction;
Irradiation;
Enzymatic reaction;
DOI:10.1002/anie.202003125
- Guidance literature:
-
With
bis(acetylacetonate)nickel(II); bis[2-(diphenylphosphino)phenyl] ether;
In
diethyl ether; toluene;
at 20 ℃;
optical yield given as %ee;
Inert atmosphere;
DOI:10.1021/ol300891k
- Guidance literature:
-
Multi-step reaction with 3 steps
1: water / tetrahydrofuran / 0 °C
2: potassium tert-butylate / tetrahydrofuran / 1 h / 0 - 20 °C
3: Gluconobacter Oxydans ene reductase; nicotinamide adenine dinucleotide phosphate; tris(2,2'-bipyridyl)ruthenium dichloride; D-glucose; glucose dehydrogenase-105 / isopropyl alcohol / 48 h / 4 °C / pH 9 / Irradiation; Enzymatic reaction
With
tris(2,2'-bipyridyl)ruthenium dichloride; D-glucose; glucose dehydrogenase-105; potassium tert-butylate; water; Gluconobacter Oxydans ene reductase; nicotinamide adenine dinucleotide phosphate;
In
tetrahydrofuran; isopropyl alcohol;
DOI:10.1002/anie.202003125