Multi-step reaction with 5 steps
1.1: sec.-butyllithium; (-)-sparteine / tert-butyl methyl ether; cyclohexane / 3 h / -78 °C / Inert atmosphere
1.2: 1 h / -78 - 20 °C / Inert atmosphere
1.3: 46 h / 20 °C / Inert atmosphere
2.1: hydrogenchloride / 1,3-dioxane / 2 h / 20 °C / Inert atmosphere
3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C / Inert atmosphere
4.1: hydrogenchloride / 1,3-dioxane / 12 h / 20 °C / Inert atmosphere
5.1: triethylamine / dichlorormethane / 18 h / 20 °C / Inert atmosphere
With
hydrogenchloride; sec.-butyllithium; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; (-)-sparteine;
In
1,3-dioxane; dichlorormethane; dichloromethane; tert-butyl methyl ether; cyclohexane;
DOI:10.1021/ja205602j