2,6-dichloro-N,N-diisopropylbenzamide

Base Information

• Chemical Name: 2,6-dichloro-N,N-diisopropylbenzamide
• CAS No.: 57409-35-5
• Molecular Formula: C₁₃H₁₇Cl₂NO
• Molecular Weight: 274.19
• Mol file: 57409-35-5.mol

Synonyms:2,6-dichloro-N,N-diisopropylbenzamide

Chemical Property of 2,6-dichloro-N,N-diisopropylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-dichloro-N,N-diisopropylbenzamide

There total 1 articles about 2,6-dichloro-N,N-diisopropylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

diisopropylamine (108-18-9) + 2,6-Dichlorobenzoyl chloride (4659-45-4) → 2,6-dichloro-N,N-diisopropylbenzamide (57409-35-5)

Guidance literature:

With triethylamine; In dichloromethane; Reflux;

Reference yield: 60.0%

2,6-dichloro-N,N-diisopropylbenzamide (57409-35-5) + ethyl acrylate (140-88-5,9003-32-1) → C18H23Cl2NO3

Guidance literature:

With silver(I) acetate; palladium diacetate; C₂₀H₁₇F₆N₃O₄; N-acetylglycine; at 80 ℃; for 24h;

DOI:10.1021/acscatal.1c02974

Reference yield:

2,6-dichloro-N,N-diisopropylbenzamide (57409-35-5) → 2,6-dichlorobenzaldehyde (83-38-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane; tetrahydrofuran / -78 - 20 °C / Inert atmosphere

2: lithium tri-t-butoxyaluminum hydride / dichloromethane; tetrahydrofuran / 8 h / Inert atmosphere

With lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/acs.joc.7b02868

upstream raw materials:

diisopropylamine

2,6-Dichlorobenzoyl chloride

Downstream raw materials:

2,6-dichlorobenzaldehyde

Refernces

• 1、 Xiao, Peihong,Tang, Zhixing,Wang, Kai,Chen, Hua,Guo, Qianyou,Chu, Yang,Gao, Lu,Song, Zhenlei. "Chemoselective Reduction of Sterically Demanding N,N-Diisopropylamides to Aldehydes". . p. 1687 - 1700. Retrieved 2018/02/23.