Glibornuride

Base Information

• Chemical Name: Glibornuride
• CAS No.: 26944-48-9
• Molecular Formula: C18H26 N2 O4 S
• Molecular Weight: 366.481
• European Community (EC) Number: 248-124-6
• UNII: VP83E7434R
• ChEMBL ID: CHEMBL529888
• DSSTox Substance ID: DTXSID001016937
• Metabolomics Workbench ID: 152038
• NCI Thesaurus Code: C123430
• Pharos Ligand ID: 3825WZZH6K62
• Wikidata: Q3772225
• Wikipedia: Glibornuride
• Mol file: 26944-48-9.mol

Synonyms:glibornuride;Gluborid;Glutril;Ro 6-4563;Ro-6-4563

Chemical Property of Glibornuride

Chemical Property:

• Melting Point: 192-195° (ethanol-water); also reported as 195-198°
• Refractive Index: 1.6930 (estimate)
• Boiling Point: °Cat760mmHg
• PKA: 5.20±0.10(Predicted)
• Flash Point: °C
• PSA: 107.37000
• Density: 1.3g/cm³
• LogP: 3.84460
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 366.16132849
• Heavy Atom Count: 25
• Complexity: 634

Purity/Quality:

99% ^*data from raw suppliers

Glibornuride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC2C3CCC(C2O)(C3(C)C)C
• Isomeric SMILES: CC1=CC=C(C=C1)S(=O)(=O)NC(=O)N[C@H]2[C@H]3CC[C@@]([C@H]2O)(C3(C)C)C
• Uses: Glibornuride has been shown to antagonize the relaxant response to the K+ channel opener cromakalim and produce airway smooth muscle relaxation. Glibornuride is associated with lactic acidosis and hypoglycemia in patients with type 2 diabetes melitus.
• Therapeutic Function: Oral hypoglycemic

Technology Process of Glibornuride

There total 5 articles about Glibornuride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ glibornuride (26944-48-9)

Guidance literature:

aus VII;

DOI:10.1007/BF00904604

Reference yield:

→ 3-endo-Tosylureido-borneol (24266-69-1,24271-66-7,24271-68-9,26901-15-5,26944-48-9,32609-19-1,41719-65-7)

Guidance literature:

3-endo-Tosylureido-campher, NaBH4, wss. Alkali (neben 3-endo-Tosylureido-isoborneol);

DOI:10.1007/BF01151769

Reference yield:

→ Glibornurid (24266-69-1,24271-66-7,24271-68-9,26901-15-5,26944-48-9,32609-19-1,41719-65-7)

Guidance literature:

entspr. Campher-Derivat, NaBH4;

Downstream raw materials:

toluene-4-sulfonamide

(4,4'-dimethyl-1,1'-biphenyl)

di(p-tolyl) disulfide

methyl p-toluene sulfonate

Refernces

• 1、 -. "Combinations comprising dipeptidylpeptidase-iv inhibitor". . . Retrieved 2008/06/13.