2,2'-Bioxazole,5,5'-diphenyl-

Base Information

• Chemical Name: 2,2'-Bioxazole,5,5'-diphenyl-
• CAS No.: 17064-30-1
• Molecular Formula: C18H12 N2 O2
• Molecular Weight: 288.305
• Mol file: 17064-30-1.mol

Synonyms:5,5'-Diphenyl-2,2'-bioxazole;POOP

Chemical Property of 2,2'-Bioxazole,5,5'-diphenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2'-Bioxazole,5,5'-diphenyl-

There total 13 articles about 2,2'-Bioxazole,5,5'-diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

5-phenyloxazole (1006-68-4) → 5,5'-diphenyl-2,2'-bi-1,3-oxazole (17064-30-1)

Guidance literature:

With copper diacetate; triphenylphosphine; copper(l) chloride; palladium dichloride; In 1,4-dioxane; dimethyl sulfoxide; at 20 - 120 ℃; for 1.08333h; regioselective reaction; Inert atmosphere;

DOI:10.1002/chem.201103813

Reference yield: 81.0%

5-phenyloxazole (1006-68-4) + [(E)-2-bromoethenyl]benzene (588-72-7,1340-14-3) → 5-phenyl-2-[(E)-2-phenylethenyl]-1,3-oxazole (3988-65-6) + 5,5'-diphenyl-2,2'-bi-1,3-oxazole (17064-30-1)

Guidance literature:

With copper(l) iodide; trans-N,N'-dimethylcyclohexane-1,2-diamine; lithium tert-butoxide; In 1,4-dioxane; at 100 ℃; for 3h; regioselective reaction; Inert atmosphere;

DOI:10.1021/ol801512q

Reference yield: 76.0%

1,3-Benzothiazole (95-16-9) + 5-phenyloxazole (1006-68-4) → 2,2'-benzothiazolyl (4271-09-4) + 2-(benzothiazol-2-yl)-5-phenyloxazole (1388625-38-4) + 5,5'-diphenyl-2,2'-bi-1,3-oxazole (17064-30-1)

Guidance literature:

With pyridine; oxygen; copper diacetate; silver carbonate; In 5,5-dimethyl-1,3-cyclohexadiene; at 140 ℃; for 24h; Reagent/catalyst; Solvent; chemoselective reaction;

DOI:10.1021/jo301128y

upstream raw materials:

N,N'-diphenacyl-oxalamide

5-phenyloxazole

trichlorophosphate

benzoyl chloride

Refernces

• 1、 Qin, Xurong,Feng, Boya,Dong, Jiaxing,Li, Xiaoyu,Xue, Ying,Lan, Jingbo,You, Jingsong. "Copper(II)-catalyzed dehydrogenative cross-coupling between two azoles". supporting information. p. 7677 - 7683. Retrieved 2012/11/06.
• 2、 Besselievre, Francois,Piguel, Sandrine,Mahuteau-Betzer, Florence,Grierson, David S.. "Stereoselective direct copper-catalyzed alkenylation of oxazoles with bromoalkenes". supporting information; experimental part. p. 4029 - 4032. Retrieved 2009/06/18.