2-(2-HYDROXY-PHENYL)-3H-QUINAZOLIN-4-ONE

Base Information

• Chemical Name: 2-(2-HYDROXY-PHENYL)-3H-QUINAZOLIN-4-ONE
• CAS No.: 1026-04-6
• Molecular Formula: C14H10 N2 O2
• Molecular Weight: 238.246
• Hs Code.: 2933990090
• Mol file: 1026-04-6.mol

Synonyms:4(1H)-Quinazolinone,2-(2-hydroxyphenyl)- (9CI); 4(3H)-Quinazolinone, 2-(o-hydroxyphenyl)-(7CI,8CI); 2-(2-Hydroxyphenyl)-4(1H)-quinazolinone; ELF 69 alcohol

Chemical Property of 2-(2-HYDROXY-PHENYL)-3H-QUINAZOLIN-4-ONE

Chemical Property:

• Vapor Pressure: 1.81E-08mmHg at 25°C
• Boiling Point: 523.7°Cat760mmHg
• Flash Point: 227.3°C
• PSA: 65.98000
• Density: 1.343g/cm³
• LogP: 2.29570

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(2-hydroxyphenyl)-4(3H)-quinazolinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-HYDROXY-PHENYL)-3H-QUINAZOLIN-4-ONE

There total 31 articles about 2-(2-HYDROXY-PHENYL)-3H-QUINAZOLIN-4-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(2'-cyanophenoxy)benzonitrile (139298-17-2) → 2-(2'-hydroxyphenyl)-4-(3H)-quinazolinone (1026-04-6)

Guidance literature:

With water; sodium hydroxide; In ethanol; Reflux;

DOI:10.1002/asia.201100832

Reference yield: 96.0%

salicylaldehyde (90-02-8) + anthranilic acid amide (28144-70-9,88-68-6) → 2-(2'-hydroxyphenyl)-4-(3H)-quinazolinone (1026-04-6)

Guidance literature:

With sulfonic acid-based ionic liquid catalyst; at 80 ℃; for 2h;

Reference yield: 92.0%

isatoic anhydride (118-48-9) + salicylaldehyde (90-02-8) → 2-(2'-hydroxyphenyl)-4-(3H)-quinazolinone (1026-04-6)

Guidance literature:

With ammonium acetate; In neat (no solvent); at 100 ℃; for 0.166667h;

DOI:10.1016/j.molcata.2013.04.002

upstream raw materials:

N-salicyliden-anthranilic acid amide

2-(phenylaminocarbonyloxy)benzonitrile

4-anilino-1,3<2H>benzoxazin-2-one

2-(2-hydroxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

Downstream raw materials:

C₃₃H₃₆N₄O₇

Refernces

• 1、 Anthony, Savarimuthu Philip. "Polymorph-dependent solid-state fluorescence and selective metal-ion-sensor properties of 2-(2-hydroxyphenyl)-4(3H)-quinazolinone". . p. 374 - 379. Retrieved 2012.
• 2、 Zhou, Yi,Liu, Meng-Meng,Li, Jing-Yun,Ye, Min-An,Yao, Cheng. "Fluorescence turn-on detection of fluoride using HPQ-silyl ether reactive probes and its in vivo application". . p. 277 - 284. Retrieved 2018.
• 3、 Hrast, Martina,Mravljak, Janez,Slavec, Lara,Sova, Matej. "Synthesis and evaluation of antioxidant properties of 2-substituted quinazolin-4(3H)-ones". . . Retrieved 2021/12/10.
• 4、 Hou, Huiqing,Ma, Xinhua,Lin, Yingying,Lin, Jin,Sun, Weiming,Wang, Lei,Xu, Xiuzhi,Ke, Fang. "Electrochemical synthesis of quinazolinone: via I2-catalyzed tandem oxidation in aqueous solution". . p. 17721 - 17726. Retrieved 2021/05/29.