1-Phenyl-2-acetamido-1,3-propandiol

Base Information

• Chemical Name: 1-Phenyl-2-acetamido-1,3-propandiol
• CAS No.: 91247-54-0
• Molecular Formula: C₁₁H₁₅NO₃
• Molecular Weight: 209.245
• Mol file: 91247-54-0.mol

Synonyms:1-Phenyl-2-acetamido-1,3-propandiol

Chemical Property of 1-Phenyl-2-acetamido-1,3-propandiol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Phenyl-2-acetamido-1,3-propandiol

There total 32 articles about 1-Phenyl-2-acetamido-1,3-propandiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dl-threo-phenylserine (69-96-5,1078-17-7,2584-74-9,2584-75-0,6254-48-4,7352-06-9,7687-36-7,7695-56-9,32946-42-2,50897-27-3,68296-26-4,109120-55-0) → (1RS,2RS)-2-acetylamino-1-phenyl-propane-1,3-diol (3313-19-7,3313-20-0,80938-70-1,91247-54-0,104485-77-0)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen chloride

2: pyridine

3: lithium aluminium hydride; diethyl ether; chloroform

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; diethyl ether; chloroform;

Reference yield:

N-phenacylacetamide (1846-33-9) → (1RS,2RS)-2-acetylamino-1-phenyl-propane-1,3-diol (3313-19-7,3313-20-0,80938-70-1,91247-54-0,104485-77-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous formaldehyde; sodium hydrogencarbonate

2: Raney nickel; methanol / Hydrogenation

With methanol; formaldehyd; nickel; sodium hydrogencarbonate;

DOI:10.1021/ja01175a067

Reference yield:

(1RS:2RS)-2-acetylamino-3-acetoxy-1-phenyl-propanol-(1) → (1RS,2RS)-2-acetylamino-1-phenyl-propane-1,3-diol (3313-19-7,3313-20-0,80938-70-1,91247-54-0,104485-77-0)

Guidance literature:

With potassium hydroxide; acetone;

DOI:10.1021/ja01175a066

upstream raw materials:

(2RS,3SR)-3-acetoxy-2-acetylamino-3-phenyl-propionic acid ethyl ester

α-acetamido-β-hydroxypropiophenone

(+/-)-threo-2-amino-1-phenyl-1,3-propanediol

acetic anhydride

Downstream raw materials:

N-[4c-(4-nitro-phenyl)-2ξ-oxo-2λ⁴-[1,3,2]dioxathian-5r-yl]-acetamide

(2RS,3RS)-3-acetoxy-2-amino-3-phenyl-propan-1-ol; hydrochloride

(+/-)-(2-methyl-5t-phenyl-4,5-dihydro-oxazol-4r-yl)-methanol

4(R*)-<(S*)-hydroxy(phenyl)methyl>-1,3-oxazolin-2-one

Refernces

• 1、 Effenberger, Franz,Gutterer, Beate,Syed, Jana. "Stereoselective Synthesis of (1R,2S)-2-Amino-1,3-diols from (R)-Cyanohydrins". . p. 2933 - 2944. Retrieved 2007/10/03.