(2,3-dichlorophenyl)-oxoacetic acid methyl ester

Base Information

• Chemical Name: (2,3-dichlorophenyl)-oxoacetic acid methyl ester
• CAS No.: 1646328-15-5
• Molecular Formula: C₉H₆Cl₂O₃
• Molecular Weight: 233.051
• Mol file: 1646328-15-5.mol

Synonyms:(2,3-dichlorophenyl)-oxoacetic acid methyl ester

Chemical Property of (2,3-dichlorophenyl)-oxoacetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2,3-dichlorophenyl)-oxoacetic acid methyl ester

There total 3 articles about (2,3-dichlorophenyl)-oxoacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 2-(2,3-dichlorophenyl)-2-oxoacetamide (180868-97-7) → (2,3-dichlorophenyl)-oxoacetic acid methyl ester (1646328-15-5)

Guidance literature:

With thionyl chloride; at 40 - 64 ℃; for 4.5h;

DOI:10.1002/jhet.1717

Reference yield:

2,3-dichlorbenzoic acid (50-45-3) → (2,3-dichlorophenyl)-oxoacetic acid methyl ester (1646328-15-5)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride

2: water; sodium chloride; sulfuric acid / 1.5 h / 40 - 45 °C

3: thionyl chloride / 4.5 h / 40 - 64 °C

With thionyl chloride; sulfuric acid; water; sodium chloride;

DOI:10.1002/jhet.1717

Reference yield:

2,3-dichlorobenzoyl cyanide (77668-42-9) → (2,3-dichlorophenyl)-oxoacetic acid methyl ester (1646328-15-5)

Guidance literature:

Multi-step reaction with 2 steps

1: water; sodium chloride; sulfuric acid / 1.5 h / 40 - 45 °C

2: thionyl chloride / 4.5 h / 40 - 64 °C

With thionyl chloride; sulfuric acid; water; sodium chloride;

DOI:10.1002/jhet.1717

upstream raw materials:

methanol

2-(2,3-dichlorophenyl)-2-oxoacetamide

2,3-dichlorbenzoic acid

2,3-dichlorobenzoyl cyanide

Refernces