Noracymethadol, (-)-

Base Information

• Chemical Name: Noracymethadol, (-)-
• CAS No.: 43033-71-2
• Molecular Formula: C₂₂H₂₉NO₂
• Molecular Weight: 339.478
• UNII: Y4G2SI35XZ
• DSSTox Substance ID: DTXSID801023502
• Nikkaji Number: J474.573F
• Wikidata: Q27149697
• Mol file: 43033-71-2.mol

Synonyms:1 alpha-acetylnormethadol;6-(methylamino)-4,4-diphenyl-3-heptanol acetate;l-alpha-noracetylmethadol;N-desmethyl-1-alpha-acetylmethadol;NLAAM;nor-LAAM;noracetylmethadol;paracymethadol;paracymethadol hydrochloride;paracymethadol hydrochloride, (R*,R*)-(+-)-isomer;paracymethadol hydrochloride, (S-(R*,R*))-isomer;paracymethadol, (R*,R*)-(+-)-isomer;paracymethadol, (R-(R*,R*))-isomer;paracymethadol, (S-(R*,R*))-(-)-isomer

Chemical Property of Noracymethadol, (-)-

Chemical Property:

• Vapor Pressure: 1.82E-08mmHg at 25°C
• Boiling Point: 455°C at 760 mmHg
• Flash Point: 229°C
• PSA: 38.33000
• Density: 1.024g/cm³
• LogP: 4.70330
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 9
• Exact Mass: 339.219829168
• Heavy Atom Count: 25
• Complexity: 379

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C(CC(C)NC)(C1=CC=CC=C1)C2=CC=CC=C2)OC(=O)C
• Isomeric SMILES: CC[C@@H](C(C[C@H](C)NC)(C1=CC=CC=C1)C2=CC=CC=C2)OC(=O)C

Technology Process of Noracymethadol, (-)-

There total 1 articles about Noracymethadol, (-)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Lg-threo-5-acetoxy-2-dimethylamino-4,4-diphenyl-heptane (1477-40-3,34433-66-4) → (-)-alpha-Noracetylmethadol (43033-71-2)

Guidance literature:

Multistep reaction; (i) carbonochloridic acid 2,2,2-trichloro-ethyl ester, benzene, (ii) HCO₂H, Et₃N, (iii) Zn, HCO₂H, DMF;

DOI:10.1021/jm00237a010

Reference yield:

(-)-alpha-Noracetylmethadol (43033-71-2) → α-(-)-4,4-Diphenyl-6-nitro-3-heptanol-acetat (55123-65-4)

Guidance literature:

With calcium sulfate; potassium permanganate; In water; tert-butyl alcohol;

DOI:10.1021/jm00237a010

Reference yield:

(-)-alpha-Noracetylmethadol (43033-71-2) → alpha-l-Normethadol (51733-60-9)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; Heating;

DOI:10.1021/jm00237a010

upstream raw materials:

L_g-threo-5-acetoxy-2-dimethylamino-4,4-diphenyl-heptane

Downstream raw materials:

(-)-α-N-(cyclopropylcarbonyl)-N-noracylmethadol

(-)-α-N-allyl-N-noracetylmethadol

α-(-)-4,4-Diphenyl-6-nitro-3-heptanol-acetat

alpha-l-Normethadol

Refernces