BUSERELIN

Base Information

• Chemical Name: BUSERELIN
• CAS No.: 68630-75-1
• Molecular Formula: C62H90N16O15
• Molecular Weight: 1239.4242
• Mol file: 68630-75-1.mol

Synonyms:S 746766;Luteinizing hormone-releasing factor (pig), 6-(O-(1,1-dimethylethyl)-D-serine)-9-(N-ethyl-L-prolinamide)-10-deglycinamide-, monoacetate (salt);Buserelina [INN-Spanish];Suprecur (TN);ICI 123215;D-Ser(tbu(sup 6))-LH-RH-(1-9)-nonapeptide ethylamide;111520-35-5;Luteinizing hormone-releasing hormone (pig), 6-(O-(1,1-dimethylethyl)-D-serine)-9-(N-ethyl-L-prolinamide)-10-deglycinamide-;1-9-Luteinizing hormone-releasing factor (swine),6-[O-(1,1-dimethylethyl)-Dserine]- 9-(N-ethyl-L-prolinamide)-,monoacetate (salt);D-Ser-(TBu)(sup 6)-LHRH-ethylamide;N-[1-[[1-[[1-[[1-[[1-[[1-[[5-(diaminomethylideneamino)-1-[2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxo-pentan-2-yl]carbamoyl]-3-methyl-butyl]carbamoyl]-2-tert-butoxy-ethyl]carbamoyl]-2-(4-hydroxyphenyl)ethyl]carbamoyl]-2-hydroxy-ethyl]carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl]-2-(3H-imidazol-4-yl)ethyl]-5-oxo-pyrrolidine-2-carboxamide;Suprecur;Buserelin acetate (JAN/USAN);Suprefact;(D-Ser(tbu)(sup 6)-EA(sup 10))-LHRH;HOE 766;Luteinizing hormone-releasing hormone, (D-ser(tbu)(sup 6)-EA(sup 10))-;(D-Ser(tbu)(sup 6)-EA(sup 10))-luteinizing hormone-releasing hormone;HOE 766MP;(D-Ser(Bu(sup t)(sup 6)))-LH-RH(1-9)nonapeptide-ethylamide;Buserelinum [INN-Latin];5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-O-tert-butyl-D-seryl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide monoacetate (salt);Buserelin acetate;104428-01-5;Busereline [INN-French];Buserelin monoacetate;Luteinizing hormone-releasing factor (pig), 6-(O-(1,1-dimethylethyl)-D-serine)-9-(N-ethyl-L-prolinamide)-10-deglycinamide-;(Des-Gly10,D-Ser(tBu)6,Pro-NHEt9)-LHRH;acetic acid; (2S)-N-[(1S)-1-[[(1S)-1-[[(1S)-1-[[(1S)-1-[[(1R)-1-[[(1S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxo-pentan-2-yl]carbamoyl]-3-methyl-butyl]carbamoyl]-2-tert-butoxy-ethyl]carbamoyl]-2-(4-hydroxyphenyl)ethyl]carbamoyl]-2-hydroxy-ethyl]carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl]-2-(3H-imidazol-4-yl)ethyl]-5-oxo-pyrrolidine-2-carboxamide;

Chemical Property of BUSERELIN

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 186-188°C
• Boiling Point: 1691.5°C at 760 mmHg
• Flash Point: 976.8°C
• PSA: 475.57000
• Density: 1.43 g/cm³
• LogP: 3.21630
• Storage Temp.: −20°C
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

Buserelin Acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 60
• Safety Statements: 53-22-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Description: Buserelin acetate is a potent analog of the hypothalamic hormone, luteinizing hormone-releasing hormone (LH-RH). Chronic administration of higher doses of buserelin desensitizes the pituitary, resulting in a decreased production of luteinizing hormone (LH), follicle stimulating hormone (FSH), and eventually sex steroids (testosterone in males and estradiol in females). Initial approval is for use in achieving medical castration in the treatment of advanced prostate cancer. It has also been investigated for the treatment of endometriosis, leiomyoma, precocious puberty, advanced breast cancer and infertility.
• Uses: Gondadotropin-releasing hormone agonist, used to treat hormone-responsive cancers such as prostate and breast cancer. Synthetic nonapeptide agonist analog of LH-RH. Antineolpastic (hormonal).