5alpha-Dihydrocorticosterone

Base Information

• Chemical Name: 5alpha-Dihydrocorticosterone
• CAS No.: 298-25-9
• Molecular Formula: C21H32O4
• Molecular Weight: 348.483
• DSSTox Substance ID: DTXSID80952235
• Nikkaji Number: J401.581I
• Wikipedia: 5%CE%B1-Dihydrocorticosterone
• Wikidata: Q20707827
• Metabolomics Workbench ID: 200434
• Mol file: 298-25-9.mol

Synonyms:5 alpha-dihydrocorticosterone;5 beta-dihydrocorticosterone;5-dihydrocorticosterone;5-dihydrocorticosterone sulfate

Chemical Property of 5alpha-Dihydrocorticosterone

Chemical Property:

• Vapor Pressure: 1.82E-12mmHg at 25°C
• Refractive Index: 1.548
• Boiling Point: 508.5 °C at 760 mmHg
• Flash Point: 275.4 °C
• PSA: 74.60000
• Density: 1.175 g/cm³
• LogP: 2.74660
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 348.23005950
• Heavy Atom Count: 25
• Complexity: 586

Purity/Quality:

99% ^*data from raw suppliers

5α-Dihydrocorticosterone(Solution) ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC12CCC(=O)CC1CCC3C2C(CC4(C3CCC4C(=O)CO)C)O
• Isomeric SMILES: C[C@]12CCC(=O)C[C@@H]1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C)O

Technology Process of 5alpha-Dihydrocorticosterone

There total 2 articles about 5alpha-Dihydrocorticosterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

corticosterone-21-acetate (1173-26-8) → Corticosterone (50-22-6) + 5α-pregnane-11β,21-diol-3,20-dione (298-25-9)

Guidance literature:

In ethanol; at 24 - 26 ℃; for 96h; Penicillium decumbens ATCC 10436, potato dextrose broth;

DOI:10.1016/0039-128X(95)00071-W

Reference yield:

→ 11α,21-Dihydroxy-3,20-dioxo-pregnadien-(1,4) (298-25-9,566-01-8)

Guidance literature:

21-Hydroxy-3,20-dioxo-pregnadien-(1,4), Sporotrichum epigaeum Kulturen bei beschraenktem Luftzutritt;

Reference yield:

5α-pregnane-11β,21-diol-3,20-dione (298-25-9) → (20Ξ)-5α-pregnanetetrol-(3β,11β,20,21) (6815-98-1,6815-99-2,7285-27-0,7791-41-5,10417-87-5,14149-84-9,32040-50-9,53494-74-9,53494-76-1,53494-77-2,53494-78-3)

Guidance literature:

With ethanol; platinum; Hydrogenation;

DOI:10.1007/BF03192451

upstream raw materials:

corticosterone-21-acetate

Downstream raw materials:

(20Ξ)-5α-pregnanetetrol-(3β,11β,20,21)

Refernces