2-amino-5-chloro-3-benzyloxypyrazine

Base Information

• Chemical Name: 2-amino-5-chloro-3-benzyloxypyrazine
• CAS No.: 1410164-77-0
• Molecular Formula: C₁₁H₁₀ClN₃O
• Molecular Weight: 235.673
• Mol file: 1410164-77-0.mol

Synonyms:2-amino-5-chloro-3-benzyloxypyrazine

Chemical Property of 2-amino-5-chloro-3-benzyloxypyrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-5-chloro-3-benzyloxypyrazine

There total 1 articles about 2-amino-5-chloro-3-benzyloxypyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

benzyl alcohol (100-51-6,185532-71-2) + 3,5-dichloro-pyrazin-2-ylamine (873-42-7) → 2-amino-5-chloro-3-benzyloxypyrazine (1410164-77-0)

Guidance literature:

benzyl alcohol; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.166667h; Inert atmosphere;

3,5-dichloro-pyrazin-2-ylamine; In tetrahydrofuran; mineral oil; for 24h; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2012.09.039 DOI:10.1016/j.tet.2012.09.039

Reference yield: 50.0%

2-amino-5-chloro-3-benzyloxypyrazine (1410164-77-0) → 5-chloro-2-iodo-3-benzyloxypyrazine (1410164-82-7)

Guidance literature:

2-amino-5-chloro-3-benzyloxypyrazine; With hydrogen iodide; In water; acetonitrile; at 0 ℃; for 0.166667h; Inert atmosphere;

With sodium nitrite; In water; acetonitrile; at 0 - 50 ℃; for 21.1667h; Inert atmosphere;

DOI:10.1016/j.tet.2012.09.039 DOI:10.1016/j.tet.2012.09.039

Reference yield: 48.0%

2-amino-5-chloro-3-benzyloxypyrazine (1410164-77-0) → 5-chloro-2-bromo-3-benzyloxypyrazine (1410164-87-2)

Guidance literature:

With copper(I) bromide; copper(ll) bromide; isopentyl nitrite; In acetonitrile; at 20 ℃; for 3h;

DOI:10.1016/j.tet.2012.09.039 DOI:10.1016/j.tet.2012.09.039

upstream raw materials:

benzyl alcohol

3,5-dichloro-pyrazin-2-ylamine

Downstream raw materials:

C₁₈H₁₅ClN₂O

C₂₅H₂₂N₂O

C₁₇H₁₂Cl₂N₂O

C₂₃H₁₆Cl₂N₂O

Refernces

• 1、 Caldwell, John J.,Veillard, Nicolas,Collins, Ian. "Design and synthesis of 2(1H)-pyrazinones as inhibitors of protein kinases". . p. 9713 - 9728. Retrieved 2013/01/13.