3,6-Diacetamidoacridine

Base Information

• Chemical Name: 3,6-Diacetamidoacridine
• CAS No.: 15724-70-6
• Molecular Formula: C17H15 N3 O2
• Molecular Weight: 293.325
• Hs Code.: 2933990090
• European Community (EC) Number: 239-819-5
• NSC Number: 7218
• UNII: 6JWL4MZ5HH
• DSSTox Substance ID: DTXSID20166233
• Nikkaji Number: J248.746B
• Wikidata: Q83035457
• ChEMBL ID: CHEMBL244683
• Mol file: 15724-70-6.mol

Synonyms:3,6-Diacetamidoacridine;15724-70-6;N-(6-acetamidoacridin-3-yl)acetamide;3,6-Bis(acetylamino)acridine;Acetamide, N,N'-3,6-acridinediylbis-;3,6-Bis-monoacetaminoacridine;N,N'-Acridine-3,6-diyldi(acetamide);MLS000736567;3, 6-Diacetamidoacridine;6JWL4MZ5HH;NSC 7218;NSC-7218;EINECS 239-819-5;N,N/'-acridine-3,6-diyldi(acetamide);SMR000528066;NSC7218;UNII-6JWL4MZ5HH;3,6-diacetamido-acridine;cid_85070;CHEMBL244683;SCHEMBL18075701;BDBM29698;DTXSID20166233;HMS2870N03;Acetamide,N'-3,6-acridinediylbis-;MFCD18429636;N,N'-(acridine-3,6-diyl)diacetamide;N-(6-acetamido-3-acridinyl)acetamide;N-(6-acetamidoacridin-3-yl)ethanamide;NCGC00246913-01;AS-76209;N-[6-(acetylamino)-3-acridinyl]acetamide;CS-0337052;D5595;N,N'-3,6-ACRIDINEDIYLBIS(ACETAMIDE);T71860

Chemical Property of 3,6-Diacetamidoacridine

Chemical Property:

• Melting Point: 270 °C
• Boiling Point: 673.9°Cat760mmHg
• PKA: 13.12±0.43(Predicted)
• Flash Point: 361.4°C
• PSA: 71.09000
• Density: 1.351g/cm³
• LogP: 3.45080
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 293.116426730
• Heavy Atom Count: 22
• Complexity: 402

Purity/Quality:

98%min ^*data from raw suppliers

3,6-Diacetamidoacridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC2=C(C=C1)C=C3C=CC(=CC3=N2)NC(=O)C

Technology Process of 3,6-Diacetamidoacridine

There total 5 articles about 3,6-Diacetamidoacridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

proflavine (92-62-6) + acetyl chloride (75-36-5) → 3,6-diacetamido-acridine (15724-70-6)

Guidance literature:

With potassium carbonate; In acetone; at 0 - 20 ℃; for 15h; Inert atmosphere;

DOI:10.1016/j.ejmech.2009.01.010

Reference yield: 43.0%

proflavine (92-62-6) + acetic anhydride (108-24-7) → 3,6-diacetamido-acridine (15724-70-6)

Guidance literature:

With sodium acetate; at 100 ℃; for 2h;

DOI:10.1007/BF00808507

Reference yield: 43.0%

3,6-diaminoacridine hemisulfate + acetic anhydride (108-24-7) → 3,6-diacetamido-acridine (15724-70-6)

Guidance literature:

With sodium acetate; at 100 ℃; for 2h;

DOI:10.1016/j.ejmech.2007.02.010

upstream raw materials:

proflavine

acetic anhydride

4,4'-methylenebis(m-nitroaniline)

4,4'-diamino diphenyl methane

Downstream raw materials:

acriflavine

Refernces

• 1、 Smith et al.. "-". . . Retrieved 1958.
• 2、 Benchabane, Yohann,Di Giorgio, Carole,Boyer, Gerard,Sabatier, Anne-Sophie,Allegro, Diane,Peyrot, Vincent,De Meo, Michel. "Photo-inducible cytotoxic and clastogenic activities of 3,6-di-substituted acridines obtained by acylation of proflavine". experimental part. p. 2459 - 2467. Retrieved 2009/11/30.