1-(2-propynyl)-4-(trifluoromethyl)piperidine

Base Information

• Chemical Name: 1-(2-propynyl)-4-(trifluoromethyl)piperidine
• CAS No.: 623948-94-7
• Molecular Formula: C₉H₁₂F₃N
• Molecular Weight: 191.196
• Hs Code.: 2933399990
• Mol file: 623948-94-7.mol

Synonyms:1-(prop-2-yn-1-yl)-4-(trifluoromethyl)piperidine

Chemical Property of 1-(2-propynyl)-4-(trifluoromethyl)piperidine

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

1-Prop-2-ynyl-4-(trifluoromethyl)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 1-(2-Propyn-1-yl)-4-(trifluoromethyl)piperidine is used as a reactant in the preparation of alkynyl-substituted spirocyclic sulfamides for treatment of Alzheimer''s disease.

Technology Process of 1-(2-propynyl)-4-(trifluoromethyl)piperidine

There total 1 articles about 1-(2-propynyl)-4-(trifluoromethyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-Trifluormethyl-piperidin (657-36-3) + propargyl bromide (106-96-7) → 1-(prop-2-yn-1-yl)-4-(trifluoromethyl)piperidine (623948-94-7)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 10h;

Reference yield: 94.0%

1-(prop-2-yn-1-yl)-4-(trifluoromethyl)piperidine (623948-94-7) + 2-[4-(ethylsulfonyl)phenyl]-N-(4-iodophenyl)acetamide → 2-(4-ethylsulfonylphenyl)-N-(4-(3-(4-(trifluoromethyl)piperidin-1-yl)prop-1-yn-1-yl)phenyl)acetamide

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 50 ℃; for 6h; Inert atmosphere;

upstream raw materials:

4-Trifluormethyl-piperidin

propargyl bromide

Refernces

• 1、 -. "ALKYNYL-SUBSTITUTED SPIROCYCLIC SULFAMIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE". Page/Page column 17-18. . Retrieved 2010/02/07.