5-fluoro-3-pyridinecarbonyl chloride

Base Information

• Chemical Name: 5-fluoro-3-pyridinecarbonyl chloride
• CAS No.: 350-04-9
• Molecular Formula: C₆H₃ClFNO
• Molecular Weight: 159.547
• Hs Code.: 2933399990
• Mol file: 350-04-9.mol

Synonyms:5-fluoro-3-pyridinecarbonyl chloride

Chemical Property of 5-fluoro-3-pyridinecarbonyl chloride

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

5-Fluoronicotinoylchloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-fluoro-3-pyridinecarbonyl chloride

There total 7 articles about 5-fluoro-3-pyridinecarbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-3-methyl-5-nitropyridine (18344-51-9) → 5-fluoro-3-pyridinecarbonyl chloride (350-04-9)

Guidance literature:

Multi-step reaction with 6 steps

1: calcium chloride; aqueous sodium nitrite solution; aqueous hydrochloric acid / Erhitzen des Reaktionsprodukts mit Wasser

2: phosphoryl chloride

3: palladium/charcoal; sodium acetate; acetic acid / Hydrogenation

4: ethyl nitrite / Erwaermen des erhaltenen Diazoniumsalzes mit Petrolaether

5: KMnO₄; H₂O

6: SOCl₂

With hydrogenchloride; potassium permanganate; palladium on activated charcoal; thionyl chloride; ethyl nitrite; water; sodium acetate; acetic acid; calcium chloride; sodium nitrite; trichlorophosphate;

DOI:10.1021/jo01154a021

Reference yield:

5-fluoropyridine-3-carboxylic acid (402-66-4) → 5-fluoro-3-pyridinecarbonyl chloride (350-04-9)

Guidance literature:

With thionyl chloride;

DOI:10.1021/jo01154a021

Reference yield:

3-methylpyridin-2-ylamine (1603-40-3) → 5-fluoro-3-pyridinecarbonyl chloride (350-04-9)

Guidance literature:

Multi-step reaction with 7 steps

1: H₂SO₄; HNO₃

2: calcium chloride; aqueous sodium nitrite solution; aqueous hydrochloric acid / Erhitzen des Reaktionsprodukts mit Wasser

3: phosphoryl chloride

4: palladium/charcoal; sodium acetate; acetic acid / Hydrogenation

5: ethyl nitrite / Erwaermen des erhaltenen Diazoniumsalzes mit Petrolaether

6: KMnO₄; H₂O

7: SOCl₂

With hydrogenchloride; potassium permanganate; palladium on activated charcoal; thionyl chloride; ethyl nitrite; sulfuric acid; water; nitric acid; sodium acetate; acetic acid; calcium chloride; sodium nitrite; trichlorophosphate;

DOI:10.1021/jo01154a021

upstream raw materials:

5-fluoropyridine-3-carboxylic acid

5-methyl-3-fluoropyridine

5-methylpyridin-3-amine

3-methylpyridin-2-ylamine

Downstream raw materials:

5-fluoropyridine-3-carbonitrile

2-bromo-1-(5-fluoropyridin-3-yl)ethanone hydrobromide

C₁₅H₈F₅N₃S

BrH*C₇H₆FNO

Refernces

• 1、 -. "INDOLE AHR INHIBITORS AND USES THEREOF". Paragraph 0034-00346. . Retrieved 2018/11/22.