Pyridin-2-yl-(3-trifluoromethyl-phenyl)-acetonitrile

Base Information

• Chemical Name: Pyridin-2-yl-(3-trifluoromethyl-phenyl)-acetonitrile
• CAS No.: 122376-69-6
• Molecular Formula: C₁₄H₉F₃N₂
• Molecular Weight: 262.234
• Mol file: 122376-69-6.mol

Synonyms:Pyridin-2-yl-(3-trifluoromethyl-phenyl)-acetonitrile

Chemical Property of Pyridin-2-yl-(3-trifluoromethyl-phenyl)-acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pyridin-2-yl-(3-trifluoromethyl-phenyl)-acetonitrile

There total 3 articles about Pyridin-2-yl-(3-trifluoromethyl-phenyl)-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

pyridine-2-acetonitrile (2739-97-1) + 3-bromo-1-trifluoromethylbenzene (401-78-5) → Pyridin-2-yl-(3-trifluoromethyl-phenyl)-acetonitrile (122376-69-6)

Guidance literature:

With potassium tert-butylate; palladium diacetate; nixantphos; In 1,4-dioxane; at 60 ℃; for 10h; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tetlet.2020.152534

Reference yield: 57.0%

2-chloropyridine (109-09-1) + 3-trifluoromethylphenylacetonitrile (2338-76-3) → Pyridin-2-yl-(3-trifluoromethyl-phenyl)-acetonitrile (122376-69-6)

Guidance literature:

With sodium amide; In toluene;

DOI:10.1002/ardp.19893220310

Reference yield:

2-bromo-pyridine (109-04-6) + 3-trifluoromethylphenylacetonitrile (2338-76-3) → Pyridin-2-yl-(3-trifluoromethyl-phenyl)-acetonitrile (122376-69-6)

Guidance literature:

3-trifluoromethylphenylacetonitrile; With potassium hydroxide; In dimethyl sulfoxide; at 60 ℃;

2-bromo-pyridine; In dimethyl sulfoxide; at 60 - 70 ℃; for 4h;

DOI:10.1016/j.bioorg.2020.103717

upstream raw materials:

2-chloropyridine

3-trifluoromethylphenylacetonitrile

2-bromo-pyridine

pyridine-2-acetonitrile

Downstream raw materials:

4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-pyridin-2-yl-2-(3-trifluoromethyl-phenyl)-butyronitrile

3-Pyridin-2-yl-3-(3-trifluoromethyl-phenyl)-propylamine

Refernces

• 1、 ?tengl, Milan,Chodkowski, Andrzej,Dawidowski, Maciej,El Harchi, Aziza,Hancox, Jules C.,Jarkovska, Dagmar,Konopelski, Piotr,Król, Marek,Mistrova, Eliska,Podsadni, Piotr,Popowicz, Grzegorz M.,Sviglerova, Jitka,Szuberski, Piotr,Szulczyk, Bart?omiej,Tur?o, Jadwiga,Ufnal, Marcin,Wróbel, Martyna Zofia,Zhang, Yihong. "Structure-activity relationship and cardiac safety of 2-aryl-2-(pyridin-2-yl)acetamides as a new class of broad-spectrum anticonvulsants derived from Disopyramide". . . Retrieved 2020/03/17.