2'-propylsulfonyl-2-(anilinomethyl)imidazoline

Base Information

• Chemical Name: 2'-propylsulfonyl-2-(anilinomethyl)imidazoline
• CAS No.: 770698-49-2
• Molecular Formula: C₁₃H₁₉N₃O₂S
• Molecular Weight: 281.379
• Mol file: 770698-49-2.mol

Synonyms:2'-propylsulfonyl-2-(anilinomethyl)imidazoline

Chemical Property of 2'-propylsulfonyl-2-(anilinomethyl)imidazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-propylsulfonyl-2-(anilinomethyl)imidazoline

There total 4 articles about 2'-propylsulfonyl-2-(anilinomethyl)imidazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-nitrobenzenesulfonic acid (80-82-0) → 2'-propylsulfonyl-2-(anilinomethyl)imidazoline (770698-49-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 0.34 g / sodium bicarbonate / H₂O / 16 h / 90 °C

2: 0.29 g / H₂ / 5percent Pd/C / ethanol / 1 h / 2585.81 Torr

3: propan-2-ol / 2 h / 130 °C

With hydrogen; sodium hydrogencarbonate; 5percent Pd/C; In ethanol; water; isopropyl alcohol;

DOI:10.1021/jm000542r

Reference yield:

2-propylsulfonyl nitrobenzene (76697-43-3) → 2'-propylsulfonyl-2-(anilinomethyl)imidazoline (770698-49-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.29 g / H₂ / 5percent Pd/C / ethanol / 1 h / 2585.81 Torr

2: propan-2-ol / 2 h / 130 °C

With hydrogen; 5percent Pd/C; In ethanol; isopropyl alcohol;

DOI:10.1021/jm000542r

Reference yield:

2-Aminophenyl-propyl-sulfon (76697-58-0) + 2-(chloromethyl)-2-imidazoline hydrochloride (13338-49-3) → 2'-propylsulfonyl-2-(anilinomethyl)imidazoline (770698-49-2)

Guidance literature:

In isopropyl alcohol; at 130 ℃; for 2h;

DOI:10.1021/jm000542r

upstream raw materials:

2-Aminophenyl-propyl-sulfon

2-(chloromethyl)-2-imidazoline hydrochloride

2-nitrobenzenesulfonic acid

2-propylsulfonyl nitrobenzene

Refernces

• 1、 Hodson, Stephen J.,Bishop, Michael J.,Speake, Jason D.,Navas III, Frank,Garrison, Deanna T.,Bigham, Eric C.,Saussy Jr., David L.,Liacos, James A.,Irving, Paul E.,Jeffrey Gobel,Sherman, Bryan W.. "2-(Anilinomethyl)imidazolines as α1 adrenergic receptor agonists: The discovery of α10 subtype selective 2′-alkylsulfonyl-substituted analogues". . p. 2229 - 2239. Retrieved 2007/10/03.