2-cyclopropyl-5-phenoxypentanoic acid

Base Information

• Chemical Name: 2-cyclopropyl-5-phenoxypentanoic acid
• CAS No.: 1646860-38-9
• Molecular Formula: C₁₄H₁₈O₃
• Molecular Weight: 234.295
• Mol file: 1646860-38-9.mol

Synonyms:2-cyclopropyl-5-phenoxypentanoic acid

Chemical Property of 2-cyclopropyl-5-phenoxypentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-cyclopropyl-5-phenoxypentanoic acid

There total 1 articles about 2-cyclopropyl-5-phenoxypentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

cyclopropyl bromide (4333-56-6,130561-87-4) + 5-phenoxyvaleric acid (7170-40-3) → 2-cyclopropyl-5-phenoxypentanoic acid (1646860-38-9)

Guidance literature:

5-phenoxyvaleric acid; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -75 - 50 ℃; for 1h;

cyclopropyl bromide; In tetrahydrofuran; at -75 - 20 ℃;

DOI:10.1002/anie.201609468

Reference yield: 87.0%

(((2-(2-iodophenyl)propan-2-yl)oxy)(trifluoromethyl)sulfane) (1584705-82-7) + 2-cyclopropyl-5-phenoxypentanoic acid (1646860-38-9) → (7-phenoxyhept-3-en-1-yl)(trifluoromethyl)sulfane

Guidance literature:

With dipotassium peroxodisulfate; sodium dodecyl sulfate; silver nitrate; In water; at 50 ℃; for 12h; Inert atmosphere;

DOI:10.1002/anie.201402573

Reference yield:

2-cyclopropyl-5-phenoxypentanoic acid (1646860-38-9) + S-(difluoromethyl) benzenesulfonothioate → (difluoromethyl)(7-phenoxyhept-2-en-1-yl)sulfane + (difluoromethyl)(7-phenoxyhept-2-en-1-yl)sulfane

Guidance literature:

With dipotassium peroxodisulfate; sodium dodecyl-sulfate; silver nitrate; In water; at 50 ℃; for 6h; Overall yield = 36 %; Optical yield = 50 %de; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201609468

upstream raw materials:

cyclopropyl bromide

5-phenoxyvaleric acid

Refernces

• 1、 Hu, Feng,Shao, Xinxin,Zhu, Dianhu,Lu, Long,Shen, Qilong. "Silver-catalyzed decarboxylative trifluoromethylthiolation of aliphatic carboxylic acids in aqueous emulsion". supporting information. p. 6105 - 6109. Retrieved 2014/06/23.