6-(morpholin-4-yl)-5-nitropyrimidin-4-amine

Base Information

• Chemical Name: 6-(morpholin-4-yl)-5-nitropyrimidin-4-amine
• CAS No.: 24957-88-8
• Molecular Formula: C8H11 N5 O3
• Molecular Weight: 225.207
• Mol file: 24957-88-8.mol

Synonyms:Morpholine,4-(6-amino-5-nitro-4-pyrimidinyl)- (8CI); NSC 39846

Chemical Property of 6-(morpholin-4-yl)-5-nitropyrimidin-4-amine

Chemical Property:

• Vapor Pressure: 4.2E-10mmHg at 25°C
• Boiling Point: 499.3°Cat760mmHg
• Flash Point: 255.8°C
• Density: 1.468g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(morpholin-4-yl)-5-nitropyrimidin-4-amine

There total 2 articles about 6-(morpholin-4-yl)-5-nitropyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.6%

morpholine (110-91-8,99108-56-2) + 6-chloro-5-nitropyrimidin-4-amine (4316-94-3) → 6-morpholino-5-nitropyrimidin-4-amine (24957-88-8)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; In acetonitrile; at 25 ℃; for 3.5h; Inert atmosphere;

DOI:10.1016/j.cclet.2016.11.019

Reference yield:

→ 6-morpholino-5-nitropyrimidin-4-amine (24957-88-8)

Guidance literature:

4-Amino-6-chlor-5-nitro-pyrimidin, Morpholin;

Reference yield:

6-morpholino-5-nitropyrimidin-4-amine (24957-88-8) → 6-morpholino-7(9)H-purine (2846-96-0)

Guidance literature:

With methanol; nickel; Hydrogenation.aufeinanderfolgendes Erhitzen des Reaktionsprodukts mit Ameisensaeure <90%ig> und mit Formamid;

DOI:10.1021/jo01108a007

upstream raw materials:

morpholine

6-chloro-5-nitropyrimidin-4-amine

Downstream raw materials:

6-morpholino-7⁽⁹⁾H-purine

Refernces