3β,5β-Dihydroxy Drospirenone Ring-opened Alcohol IMpurity

Base Information

• Chemical Name: 3β,5β-Dihydroxy Drospirenone Ring-opened Alcohol IMpurity
• CAS No.: 82543-18-8
• Molecular Formula: C₂₄H₃₈O₄
• Molecular Weight: 390.563
• Mol file: 82543-18-8.mol

Synonyms:17α-(3-hydroxypropyl)-6β,7β;15β,16β-dimethylene-5β-androstane-3β,5,17β-triol

Chemical Property of 3β,5β-Dihydroxy Drospirenone Ring-opened Alcohol IMpurity

Chemical Property:

• Vapor Pressure: 0.001Pa at 25℃
• Melting Point: 130-138°C
• Boiling Point: 545.9±50.0 °C(Predicted)
• PKA: 14.54±0.70(Predicted)
• Density: 1.270±0.06 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

95%min ^*data from raw suppliers

3β,5β-DihydroxyDrospirenoneRing-openedAlcoholImpurity ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3β,5β-Dihydroxy Drospirenone Ring-opened Alcohol IMpurity

There total 4 articles about 3β,5β-Dihydroxy Drospirenone Ring-opened Alcohol IMpurity which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

17α-(3-hydroxy-1-propinyl)-6β,7β;15β,16β-dimethylene-5β-androstane-3β,5,17β-triol (82543-17-7) → 17α-(3-hydroxypropyl)-6β,7β;15β,16β-dimethylene-5β-androstane-3β,5,17β-triol (82543-18-8)

Guidance literature:

With hydrogen; Lindlar's catalyst; In tetrahydrofuran; isopropyl alcohol; for 2h; under 750.06 Torr; Ambient temperature;

Reference yield:

17α-(3-hydroxy-1-propinyl)-6β,7β;15β,16β-dimethylene-5β-androstane-3β,5,17β-triol (82543-17-7) → C24H36O4 + C24H36O4 + 17α-(3-hydroxypropyl)-6β,7β;15β,16β-dimethylene-5β-androstane-3β,5,17β-triol (82543-18-8)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In tetrahydrofuran; pyridine; methanol; at 20 - 25 ℃; for 2h; under 760.051 Torr;

Reference yield:

17α-(3-hydroxy-1-propinyl)-6β,7β;15β,16β-dimethylene-5β-androstane-3β,5,17β-triol (82543-17-7) → 6β,7β;15β,16β-dimethylene-3β,5β-dihydroxy-17α-pregn-21,17-carbolactols (1079392-41-8) + 17α-(3-hydroxypropyl)-6β,7β;15β,16β-dimethylene-5β-androstane-3β,5,17β-triol (82543-18-8)

Guidance literature:

With hydrogen; triethylamine; Lindlar's catalyst; In tetrahydrofuran; at 20 ℃; for 16h; Product distribution / selectivity;

upstream raw materials:

17α-(3-hydroxy-1-propinyl)-6β,7β;15β,16β-dimethylene-5β-androstane-3β,5,17β-triol

7β-hydroxy-15β,16β-methylene-3β-pivaloyloxy-5-androsten-17-one

Downstream raw materials:

dihydrospirorenone

5β-hydroxy-3-carbonyl-6β,7β,5β,16β-dimethylene-17α-pregna-21,17-carboxylactone

Spirorenone

Refernces

• 1、 -. "A PROCESS FOR PREPARING DROSPIRENONE AND INTERMEDIATE THEREOF". Page/Page column 17. . Retrieved 2009/01/20.
• 2、 -. "Process for the preparation of drospirenone". Page/Page column 7. . Retrieved 2008/06/13.