Technology Process of 1-<2,3,5-tri-O-benzyl-4-thio-α-D-ribofuranosyl>-N4-benzoyl-cytosine
There total 5 articles about 1-<2,3,5-tri-O-benzyl-4-thio-α-D-ribofuranosyl>-N4-benzoyl-cytosine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 75 percent / BF3*Et2O / 48 h / 0 °C
2: 80 percent / Ph3P, DEAD / tetrahydrofuran / 3 h / Ambient temperature
3: 91 percent / K2CO3 / CH2Cl2; methanol / 1 h / Ambient temperature
4: 1.) MsCl, pyridine, 2.) NBu4I, BaCO3, pyridine
5: Hg(OAc)2
6: 1.) BSA, 2.) TMSTf / 1.) MeCN, reflux, 2.) room temperature, 7 h
With
pyridine; benzenesulfonamide; TMSTf; boron trifluoride diethyl etherate; mercury(II) diacetate; tetra-(n-butyl)ammonium iodide; potassium carbonate; methanesulfonyl chloride; triphenylphosphine; barium carbonate; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1080/15257779408013205
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 80 percent / Ph3P, DEAD / tetrahydrofuran / 3 h / Ambient temperature
2: 91 percent / K2CO3 / CH2Cl2; methanol / 1 h / Ambient temperature
3: 1.) MsCl, pyridine, 2.) NBu4I, BaCO3, pyridine
4: Hg(OAc)2
5: 1.) BSA, 2.) TMSTf / 1.) MeCN, reflux, 2.) room temperature, 7 h
With
pyridine; benzenesulfonamide; TMSTf; mercury(II) diacetate; tetra-(n-butyl)ammonium iodide; potassium carbonate; methanesulfonyl chloride; triphenylphosphine; barium carbonate; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1080/15257779408013205
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 91 percent / K2CO3 / CH2Cl2; methanol / 1 h / Ambient temperature
2: 1.) MsCl, pyridine, 2.) NBu4I, BaCO3, pyridine
3: Hg(OAc)2
4: 1.) BSA, 2.) TMSTf / 1.) MeCN, reflux, 2.) room temperature, 7 h
With
pyridine; benzenesulfonamide; TMSTf; mercury(II) diacetate; tetra-(n-butyl)ammonium iodide; potassium carbonate; methanesulfonyl chloride; barium carbonate;
In
methanol; dichloromethane;
DOI:10.1080/15257779408013205