methyl-β-cyano-L-α-carbo benzoxyaminopropionate

Base Information

• Chemical Name: methyl-β-cyano-L-α-carbo benzoxyaminopropionate
• CAS No.: 4909-53-9
• Molecular Formula: C₁₃H₁₄N₂O₄
• Molecular Weight: 262.265
• Mol file: 4909-53-9.mol

Synonyms:methyl-β-cyano-L-α-carbo benzoxyaminopropionate

Chemical Property of methyl-β-cyano-L-α-carbo benzoxyaminopropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl-β-cyano-L-α-carbo benzoxyaminopropionate

There total 3 articles about methyl-β-cyano-L-α-carbo benzoxyaminopropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N-(benzyloxycarbonyl)-3-cyano-L-alanine (3309-41-9) + diazomethyl-trimethyl-silane (18107-18-1) → methyl-β-cyano-L-α-carbo benzoxyaminopropionate (4909-53-9)

Guidance literature:

In methanol; benzene; at 25 ℃; for 1h;

DOI:10.1021/jo970560p

Reference yield: 74.0%

N-(benzyloxycarbonyl)asparagine methyl ester (4668-37-5) → methyl-β-cyano-L-α-carbo benzoxyaminopropionate (4909-53-9)

Guidance literature:

With di-morpholin-4-yl-phosphinic acid chloride; triethylamine; In dichloromethane; at 20 ℃; for 5h;

DOI:10.1016/j.tetlet.2020.152747

Reference yield:

→ methyl-β-cyano-L-α-carbo benzoxyaminopropionate (4909-53-9)

Guidance literature:

DOI:10.1021/ja01066a033

upstream raw materials:

N-(benzyloxycarbonyl)asparagine methyl ester

N-(benzyloxycarbonyl)-3-cyano-L-alanine

diazomethyl-trimethyl-silane

Downstream raw materials:

N-Benzyloxycarbonyl-β-cyano-L-alanin-(4-nitro-phenylester)

(S)-2-[(2R,3R)-2-tert-Butoxycarbonylamino-3-(4-fluoro-3-nitro-phenyl)-3-hydroxy-propionylamino]-3-cyano-propionic acid methyl ester

N-(benzyloxycarbonyl)-3-cyano-L-alanine

Refernces

• 1、 Boger, Dale L.,Borzilleri, Robert M.,Nukui, Seiji,Beresis, Richard T.. "Synthesis of the vancomycin CD and DE ring systems". . p. 4721 - 4736. Retrieved 2007/10/03.