Technology Process of ethyl (2S,3R)-3-azido-2-hydroxy-4-phenylbutanoate
There total 2 articles about ethyl (2S,3R)-3-azido-2-hydroxy-4-phenylbutanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) lithium hexamethyldisilazide (LiHMDS) / 1.) hexane, THF, -78 deg C, 10 min, 2.) 15 min
2: 79 percent / triphenylphosphine, diethyl azodicarboxylate (DEAD), diphenylphosphoryl azide (DPPA) / tetrahydrofuran / 48 h / 20 °C
3: 59 percent / HCl / 10 h / Heating
With
hydrogenchloride; diphenylphosphoranyl azide; triphenylphosphine; lithium hexamethyldisilazane; diethylazodicarboxylate;
In
tetrahydrofuran;
DOI:10.1021/jo00278a050
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 79 percent / triphenylphosphine, diethyl azodicarboxylate (DEAD), diphenylphosphoryl azide (DPPA) / tetrahydrofuran / 48 h / 20 °C
2: 59 percent / HCl / 10 h / Heating
With
hydrogenchloride; diphenylphosphoranyl azide; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran;
DOI:10.1021/jo00278a050
- Guidance literature:
-
With
lithium hydroxide;
In
tetrahydrofuran; water;
at 0 ℃;
for 1h;
DOI:10.1021/jo00278a050
