2,4,6-trifluorophenylurethane

Base Information

• Chemical Name: 2,4,6-trifluorophenylurethane
• CAS No.: 130409-77-7
• Molecular Formula: C₉H₈F₃NO₂
• Molecular Weight: 219.163
• Mol file: 130409-77-7.mol

Synonyms:2,4,6-trifluorophenylurethane

Chemical Property of 2,4,6-trifluorophenylurethane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4,6-trifluorophenylurethane

There total 3 articles about 2,4,6-trifluorophenylurethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

N-(2.4-Difluor-phenyl)-carbamidsaeureethylester (2145-87-1) → 2,4,6-trifluorophenylurethane (130409-77-7)

Guidance literature:

With 2,3,4,5,6-pentachloro-1-fluoropyridin-1-ium trifluoromethanesulfonate; In dichloromethane; at 0 - 20 ℃; for 22h;

DOI:10.1021/ja00179a047

Reference yield:

N-carboethoxyaniline (101-99-5) → 2,4,6-trifluorophenylurethane (130409-77-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 21 percent / N-fluoropentachloropyridinium triflate / CH₂Cl₂ / 5 h / 0 - 20 °C

2: 68 percent / N-fluoropentachloropyridinium triflate / CH₂Cl₂ / 22 h / 0 - 20 °C

3: 17 percent / N-fluoropentachloropyridinium triflate / CH₂Cl₂ / 22 h / 0 - 20 °C

With 2,3,4,5,6-pentachloro-1-fluoropyridin-1-ium trifluoromethanesulfonate; In dichloromethane;

DOI:10.1021/ja00179a047

Reference yield:

ethyl 4-fluorophenylcarbamate (457-77-2) → 2,4,6-trifluorophenylurethane (130409-77-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / N-fluoropentachloropyridinium triflate / CH₂Cl₂ / 22 h / 0 - 20 °C

2: 17 percent / N-fluoropentachloropyridinium triflate / CH₂Cl₂ / 22 h / 0 - 20 °C

With 2,3,4,5,6-pentachloro-1-fluoropyridin-1-ium trifluoromethanesulfonate; In dichloromethane;

DOI:10.1021/ja00179a047

upstream raw materials:

N-(2.4-Difluor-phenyl)-carbamidsaeureethylester

N-carboethoxyaniline

ethyl 4-fluorophenylcarbamate

Refernces