1-Methyl-1-phenylhydrazine

Base Information

• Chemical Name: 1-Methyl-1-phenylhydrazine
• CAS No.: 618-40-6
• Molecular Formula: C7H10N2
• Molecular Weight: 122.17
• Hs Code.: 29280090
• European Community (EC) Number: 210-547-9
• NSC Number: 525518
• UNII: YHB9CZB63U
• DSSTox Substance ID: DTXSID2060678
• Nikkaji Number: J29.560D
• Wikidata: Q27294527
• Mol file: 618-40-6.mol

Synonyms:N-methyl-N-phenyl-hydrazine

Chemical Property of 1-Methyl-1-phenylhydrazine

Chemical Property:

• Appearance/Colour: clear yellow to orange-brown liquid
• Vapor Pressure: 0.0324mmHg at 25°C
• Melting Point: 1.066 g/cm³
• Refractive Index: n20/D 1.583(lit.)
• Boiling Point: 243.3 °C at 760 mmHg
• PKA: 5.37±0.10(Predicted)
• Flash Point: 93.6 °C
• PSA: 29.26000
• Density: 1.038
• LogP: 1.69680
• Storage Temp.: 0-6°C
• Water Solubility.: Slightly soluble
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 122.084398327
• Heavy Atom Count: 9
• Complexity: 77

Purity/Quality:

99.5% ^*data from raw suppliers

1-Methyl-1-phenylhydrazine >95.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN(C1=CC=CC=C1)N
• Uses: 1-Methyl-1-phenylhydrazine is used to make other chemicals.

Technology Process of 1-Methyl-1-phenylhydrazine

There total 50 articles about 1-Methyl-1-phenylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-methyl-N-nitrosoaniline (614-00-6) → 1-Methyl-1-phenylhydrazine (618-40-6)

Guidance literature:

With Ti(II)reagent(A); In diethyl ether; for 0.5h; Ambient temperature;

DOI:10.1016/0040-4020(82)80184-1

Reference yield: 89.0%

3-amino-4,5-dihydro-1,4-dimethyl-1-phenyl-1H-pyrazolium iodide (84533-99-3) → 1-Methyl-1-phenylhydrazine (618-40-6)

Guidance literature:

With sodium hydroxide; for 6.5h; Heating;

Reference yield: 89.0%

3-amino-4,5-dihydro-1,4-dimethyl-1-phenyl-1H-pyrazolium iodide (84533-99-3) → 3-hydroxypropanoic acid sodium salt (6487-38-3) + 1-Methyl-1-phenylhydrazine (618-40-6)

Guidance literature:

With sodium hydroxide; for 6.5h; Mechanism; Heating; var. 1,1-disubstituted-3-amino-4,5-dihydro-1H-pyrazolium halides;

upstream raw materials:

N-methyl-N-nitrosoaniline

acetic acid

sodium acetate

N-methyl-N-nitroaniline

Downstream raw materials:

N-methyl-N-phenyl-formamidrazone

2-pyridinecarboxaldehyde N-methyl-N-phenylhydrazone

N-methyl-N-[(E)-4-pyridylmethyleneamino]aniline

2-(N-methyl-N-phenylamino)-1H-isoindole-1,3(2H)-dione

Refernces

• 1、 Wu, Weiping,Fan, Shuaixin,Li, Tielei,Fang, Lili,Chu, Benfa,Zhu, Jin. "Cobalt-Catalyzed, Directed Intermolecular C-H Bond Functionalization for Multiheteroatom Heterocycle Synthesis: The Case of Benzotriazine". supporting information. p. 5652 - 5657. Retrieved 2021/08/01.
• 2、 Golubev, Pavel,Krasavin, Mikhail. "N-Isocyanodialkylamines generated in situ for the Joullié–Ugi reaction with indolenines". supporting information. p. 3532 - 3536. Retrieved 2018/08/29.