Boc-D-Phe(4-AMe)-OH*CH₃COOH

Base Information

• Chemical Name: Boc-D-Phe(4-AMe)-OH*CH₃COOH
• CAS No.: 1354578-13-4
• Molecular Formula: C₂H₄O₂*C₁₅H₂₂N₂O₄
• Molecular Weight: 354.403
• Mol file: 1354578-13-4.mol

Synonyms:Boc-D-Phe(4-AMe)-OH*CH₃COOH

Chemical Property of Boc-D-Phe(4-AMe)-OH*CH₃COOH

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-D-Phe(4-AMe)-OH*CH₃COOH

There total 4 articles about Boc-D-Phe(4-AMe)-OH*CH₃COOH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic acid (64-19-7,77671-22-8) + (2R)-2-[(tert-butoxy)carbonylamino]-3-(4-cyanophenyl)propanoic acid (146727-62-0) → Boc-D-Phe(4-AMe)-OH*CH3COOH (1354578-13-4)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; at 40 ℃;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → Boc-D-Phe(4-AMe)-OH*CH3COOH (1354578-13-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water; tert-butyl alcohol / 20 °C

2: hydrogen / palladium 10% on activated carbon / 40 °C

With hydrogen; sodium hydroxide; palladium 10% on activated carbon; In water; tert-butyl alcohol;

Reference yield:

(2R)-2-amino-3-(4-cyanophenyl)propanoic acid (263396-44-7) → Boc-D-Phe(4-AMe)-OH*CH3COOH (1354578-13-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water; tert-butyl alcohol / 20 °C

2: hydrogen / palladium 10% on activated carbon / 40 °C

With hydrogen; sodium hydroxide; palladium 10% on activated carbon; In water; tert-butyl alcohol;

upstream raw materials:

di-tert-butyl dicarbonate

acetic acid

(2R)-2-[(tert-butoxy)carbonylamino]-3-(4-cyanophenyl)propanoic acid

(2R)-2-amino-3-(4-cyanophenyl)propanoic acid

Downstream raw materials:

Boc-D-Phe(4-Tfa-AMe)-OH

Boc-D-Phe(4-Tfa-AMe)-Phe(4-Tfa-AMe)-4-cyanobenzylamide

H-D-Phe(4-Tfa-AMe)-Phe(4-Tfa-AMe)-4-cyanobenzylamide*HCl

Bzls-D-Phe(4-Tfa-AMe)-Phe(4-Tfa-AMe)-4-cyanobenzylamide

Refernces

• 1、 Saupe, Sebastian M.,Steinmetzer, Torsten. "A new strategy for the development of highly potent and selective plasmin inhibitors". . p. 1171 - 1180. Retrieved 2012/04/17.