Technology Process of 3-(2-(5-methylpyridin-2-yl)ethynyl)-5-bromobenzonitrile
There total 5 articles about 3-(2-(5-methylpyridin-2-yl)ethynyl)-5-bromobenzonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-methyl-2-((trimethylsilyl)ethynyl)pyridine; 3,5-dibromobenzonitrile;
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at 20 ℃;
for 3h;
DOI:10.1016/j.bmcl.2011.04.047
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine
2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 20 °C
2.2: 3 h / 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine;
In
N,N-dimethyl-formamide;
1.1: Sonogashira coupling / 2.1: Sonogashira coupling;
DOI:10.1016/j.bmcl.2011.04.047
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: ammonium hydroxide / 20 °C / Cooling with ice
2.1: thionyl chloride / 18 h / Reflux
3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 20 °C
3.2: 3 h / 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; ammonium hydroxide; copper(l) iodide; thionyl chloride; triethylamine;
In
N,N-dimethyl-formamide;
3.1: Sonogashira coupling;
DOI:10.1016/j.bmcl.2011.04.047
