2'-HYDROXY-3',4'-DIMETHOXYACETOPHENONE

Base Information

• Chemical Name: 2'-HYDROXY-3',4'-DIMETHOXYACETOPHENONE
• CAS No.: 5396-18-9
• Molecular Formula: C10H12O4
• Molecular Weight: 196.203
• Hs Code.: 29145090
• Mol file: 5396-18-9.mol

Synonyms:Acetophenone,2'-hydroxy-3',4'-dimethoxy- (6CI,7CI,8CI);1-(2-Hydroxy-3,4-dimethoxyphenyl)ethanone;2'-Hydroxy-3',4'-dimethoxyacetophenone;3,4-Dimethoxy-2-hydroxyacetophenone;Gallacetophenone-3,4-O-dimethyl ether;NSC1181;

Chemical Property of 2'-HYDROXY-3',4'-DIMETHOXYACETOPHENONE

Chemical Property:

• Melting Point: 75-77 °C
• Boiling Point: 308.1 °C at 760 mmHg
• PKA: 9.79±0.15(Predicted)
• Flash Point: 119.1 °C
• PSA: 55.76000
• Density: 1.172 g/cm³
• LogP: 1.61200
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

Gallacetophenone 3′,4′-dimethyl ether ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Gallacetophenone 3’,4’-Dimethyl ether is a phenolic compound with potential 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging activity.

Technology Process of 2'-HYDROXY-3',4'-DIMETHOXYACETOPHENONE

There total 19 articles about 2'-HYDROXY-3',4'-DIMETHOXYACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2',3',4'-trimethoxyacetophenone (13909-73-4) → 2'-hydroxy-3',4'-dimethoxyacetophenone (5396-18-9)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at -5 - 25 ℃;

DOI:10.3184/030823410X12708998015900

Reference yield: 79.8%

2',3',4'-trihydroxyacetophenone (528-21-2) + dimethyl sulfate (77-78-1) → 2'-hydroxy-3',4'-dimethoxyacetophenone (5396-18-9)

Guidance literature:

With potassium carbonate; In acetone; for 12h; Heating;

DOI:10.1002/ardp.200700077

Reference yield: 68.0%

2',3',4'-trihydroxyacetophenone (528-21-2) + methyl iodide (74-88-4) → 2'-hydroxy-3',4'-dimethoxyacetophenone (5396-18-9)

Guidance literature:

With potassium carbonate; In acetone; for 2h; Heating;

DOI:10.1021/np000489+

upstream raw materials:

2',3',4'-trimethoxyacetophenone

2,3-dimethoxyphenyl acetate

1,2,3-trimethoxybenzene

acetyl chloride

Downstream raw materials:

5t-phenyl-1-(2-hydroxy-3.4-dimethoxy-phenyl)-pentadien-(2t.4)-one-⁽¹⁾

3,4-methylenedioxy-3',4'-dimethoxy-2'-hydroxychalcone

7,8-dimethoxy-4-methyl-3-phenyl-coumarin

2'-benzyloxy-3',4'-dimethoxyacetophenone

Refernces

• 1、 Sum, Tze Han,Sum, Tze Jing,Stokes, Jamie E.,Galloway, Warren R.J.D.,Spring, David R.. "Divergent and concise total syntheses of dihydrochalcones and 5-deoxyflavones recently isolated from Tacca species and Mimosa diplotricha". . p. 4557 - 4564. Retrieved 2015/06/08.
• 2、 Qi, Ping,Jiang, Jianhua,Qi, Huan,Jin, Yinghua,Shen, Qirong,Wu, Yingliang,Song, Hongrui,Zhang, Weige. "Synthesis and antiproliferative activity of new polyoxo 2-Benzyl-2,3-dihydrobenzofurans and their related compounds". . p. 886 - 894. Retrieved 2013/12/04.