C₁₅H₁₈O₄

Base Information

• Chemical Name: C₁₅H₁₈O₄
• CAS No.: 1417719-37-9
• Molecular Formula: C₁₅H₁₈O₄
• Molecular Weight: 262.306
• Mol file: 1417719-37-9.mol

Synonyms:C₁₅H₁₈O₄

Chemical Property of C₁₅H₁₈O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of C₁₅H₁₈O₄

There total 1 articles about C₁₅H₁₈O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-4-methoxycinnamyl bromide (90841-43-3,16034-99-4) + acetoacetic acid methyl ester (105-45-3) → C15H18O4 (1417719-37-9)

Guidance literature:

acetoacetic acid methyl ester; With tetra-(n-butyl)ammonium iodide; sodium hydride; In 1,2-dimethoxyethane; at 0 ℃; for 1h; Inert atmosphere;

(E)-4-methoxycinnamyl bromide; In 1,2-dimethoxyethane; at 0 - 85 ℃; Inert atmosphere;

DOI:10.1021/ol303217s

Reference yield:

C15H18O4 (1417719-37-9) → (E)-methyl 2-diazo-5-(4-methoxyphenyl)pent-4-enoate (1417719-44-8)

Guidance literature:

C₁₅H₁₈O₄; With 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 ℃; for 3h; Inert atmosphere;

With sodium hydroxide; In dichloromethane; water; at 0 - 20 ℃;

DOI:10.1021/ol303217s

Reference yield:

C15H18O4 (1417719-37-9) → (1S,2S,3R)-methyl 2-(4-methoxyphenyl)bicyclo[1.1.0]butane-1-carboxylate (1417719-53-9) + (1R,2R,3S)-methyl 2-(4-methoxyphenyl)bicyclo[1.1.0]butane-1-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1.1: 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 3 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C

2.1: Rh₂(S-BTPCP)4 / ethyl acetate / 0.75 h / 20 °C / Inert atmosphere

With 4-acetamidobenzenesulfonyl azide; Rh₂(S-BTPCP)4; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; ethyl acetate;

DOI:10.1021/ol303217s

upstream raw materials:

(E)-4-methoxycinnamyl bromide

acetoacetic acid methyl ester

Downstream raw materials:

(1S,2S,3R)-methyl 2-(4-methoxyphenyl)bicyclo[1.1.0]butane-1-carboxylate

(E)-methyl 2-diazo-5-(4-methoxyphenyl)pent-4-enoate

Refernces