Technology Process of 5-(3-(6-chloropyridin-2-yl)-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,3,4-oxadiazol-2-amine
There total 9 articles about 5-(3-(6-chloropyridin-2-yl)-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,3,4-oxadiazol-2-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium phosphate;
tetrakis(triphenylphosphine) palladium(0);
In
N,N-dimethyl-formamide;
at 85 ℃;
for 5h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: potassium carbonate / N,N-dimethyl-formamide / 1.25 h / 65 - 80 °C
2: hydrazine / ethanol / 12 h / Reflux
3: ethanol / 2 h / Reflux
4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / toluene / 12 h / Reflux
5: potassium hydroxide; iodine / N,N-dimethyl-formamide / 1 h / 20 °C
6: sodium hydride / N,N-dimethyl-formamide; mineral oil / -25 °C
7: potassium phosphate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 5 h / 85 °C / Inert atmosphere
With
potassium phosphate; iodine; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; hydrazine;
tetrakis(triphenylphosphine) palladium(0);
In
ethanol; N,N-dimethyl-formamide; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: ethanol / 2 h / Reflux
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / toluene / 12 h / Reflux
3: potassium hydroxide; iodine / N,N-dimethyl-formamide / 1 h / 20 °C
4: sodium hydride / N,N-dimethyl-formamide; mineral oil / -25 °C
5: potassium phosphate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 5 h / 85 °C / Inert atmosphere
With
potassium phosphate; iodine; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide;
tetrakis(triphenylphosphine) palladium(0);
In
ethanol; N,N-dimethyl-formamide; toluene; mineral oil;