C₃₂H₃₇ClN₄O₅

Base Information

• Chemical Name: C₃₂H₃₇ClN₄O₅
• CAS No.: 1092069-94-7
• Molecular Formula: C₃₂H₃₇ClN₄O₅
• Molecular Weight: 593.123
• Mol file: 1092069-94-7.mol

Synonyms:C₃₂H₃₇ClN₄O₅

Chemical Property of C₃₂H₃₇ClN₄O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₃₇ClN₄O₅

There total 5 articles about C₃₂H₃₇ClN₄O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(tert-butoxycarbonyl)amino](2-chlorophenyl)acetic acid (313490-25-4,225918-60-5) + CH4O3S*C19H23N3O2 (1092069-34-5) → C32H37ClN4O5 (1092069-94-7)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; Molecular sieve;

Reference yield:

benzyl 4-(4-aminophenyl)piperazine-1-carboxylate (947673-12-3) → C32H37ClN4O5 (1092069-94-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: thionyl chloride / 0.75 h / 60 °C

1.2: 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Molecular sieve

With thionyl chloride; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide;

Reference yield:

benzyl 4-(4-nitrophenyl)piperazine-1-carboxylate (947673-13-4) → C32H37ClN4O5 (1092069-94-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogen / 5 % platinum on carbon / tetrahydrofuran; methanol / 50 °C

2.1: thionyl chloride / 0.75 h / 60 °C

2.2: 0 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

4.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Molecular sieve

With thionyl chloride; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 5 % platinum on carbon; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

upstream raw materials:

[(tert-butoxycarbonyl)amino](2-chlorophenyl)acetic acid

CH₄O₃S*C₁₉H₂₃N₃O₂

benzyl 4-(4-aminophenyl)piperazine-1-carboxylate

benzyl 4-(4-nitrophenyl)piperazine-1-carboxylate

Downstream raw materials:

C₂₇H₂₉ClN₄O₃

Refernces