Technology Process of Caulerpenyne
There total 10 articles about Caulerpenyne which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: CuCN; BuLi; Bu3SnH / MeOH / tetrahydrofuran; hexane / -40 °C
1.2: 193 mg / I2 / diethyl ether / 2 h / 20 °C
2.1: 98 percent / Dess-Martin periodinane / CH2Cl2 / 20 °C
3.1: 96 percent / DMAP; pyridine
4.1: BuLi / tetrahydrofuran / 1.5 h / -78 °C
4.2: Me3SnCl / tetrahydrofuran / -78 - 20 °C
4.3: 90 mg / PdCl2(MeCN)2 / dimethylformamide / 20 °C
5.1: 76 percent / HF/pyridine / tetrahydrofuran / 20 °C
6.1: Dess-Martin periodinane / CH2Cl2 / 20 °C
7.1: DMAP; Et3N / 80 °C
With
pyridine; dmap; n-butyllithium; hydrogen fluoride; tri-n-butyl-tin hydride; Dess-Martin periodane; triethylamine;
methanol;
In
tetrahydrofuran; hexane; dichloromethane;
2.1: Dess-Martin oxidation / 5.3: Stille cross-coupling / 7.1: Dess-Martin oxidation;
DOI:10.1055/s-2005-921760
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triphenylphosphine; zinc / CH2Cl2 / 24 h / 20 °C
1.2: 100 percent / CH2Cl2 / 2 h / 20 °C
2.1: BuLi / tetrahydrofuran / 1.5 h / -78 °C
2.2: Me3SnCl / tetrahydrofuran / -78 - 20 °C
2.3: 90 mg / PdCl2(MeCN)2 / dimethylformamide / 20 °C
3.1: 76 percent / HF/pyridine / tetrahydrofuran / 20 °C
4.1: Dess-Martin periodinane / CH2Cl2 / 20 °C
5.1: DMAP; Et3N / 80 °C
With
pyridine; dmap; n-butyllithium; hydrogen fluoride; Dess-Martin periodane; triethylamine; triphenylphosphine; zinc;
In
tetrahydrofuran; dichloromethane;
2.3: Stille cross-coupling / 4.1: Dess-Martin oxidation;
DOI:10.1055/s-2005-921760
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: BuLi / tetrahydrofuran / 1.5 h / -78 °C
1.2: Me3SnCl / tetrahydrofuran / -78 - 20 °C
1.3: 90 mg / PdCl2(MeCN)2 / dimethylformamide / 20 °C
2.1: 76 percent / HF/pyridine / tetrahydrofuran / 20 °C
3.1: Dess-Martin periodinane / CH2Cl2 / 20 °C
4.1: DMAP; Et3N / 80 °C
With
pyridine; dmap; n-butyllithium; hydrogen fluoride; Dess-Martin periodane; triethylamine;
In
tetrahydrofuran; dichloromethane;
1.3: Stille cross-coupling / 3.1: Dess-Martin oxidation;
DOI:10.1055/s-2005-921760