3-formyl-4-(trans-2-phenylethenyl)thiophen azine

Base Information

• Chemical Name: 3-formyl-4-(trans-2-phenylethenyl)thiophen azine
• CAS No.: 75997-14-7
• Molecular Formula: C₂₆H₂₀N₂S₂
• Molecular Weight: 424.59
• Mol file: 75997-14-7.mol

Synonyms:3-formyl-4-(trans-2-phenylethenyl)thiophen azine

Chemical Property of 3-formyl-4-(trans-2-phenylethenyl)thiophen azine

Chemical Property:

Purity/Quality:

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Technology Process of 3-formyl-4-(trans-2-phenylethenyl)thiophen azine

There total 6 articles about 3-formyl-4-(trans-2-phenylethenyl)thiophen azine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

4-[2-phenylethenyl]thiophene-3-carbaldehyde (75997-18-1) → 3-formyl-4-(trans-2-phenylethenyl)thiophen azine (75997-14-7)

Guidance literature:

With hydrogenchloride; hydrazine hydrate; In ethanol; at 50 ℃;

Reference yield: 7.0%

3-formyl-4-(trans-2-phenylethenyl)thiophen tosylhydrazone sodium salt (75997-13-6) → 3-(2,3-dimethoxypropyl)-4-(trans-2-phenylethenyl)thiophen (75997-15-8) + 3-<2-(2-methoxyethoxy)ethyl>-4-(trans-2-phenylethenyl)thiophen (75997-16-9) + 3-formyl-4-(trans-2-phenylethenyl)thiophen azine (75997-14-7)

Guidance literature:

In 1,2-dimethoxyethane; for 0.666667h; Heating;

Reference yield: 7.0%

3-formyl-4-(trans-2-phenylethenyl)thiophen tosylhydrazone sodium salt (75997-13-6) → 3-(2,3-dimethoxypropyl)-4-(trans-2-phenylethenyl)thiophen (75997-15-8) + 3-<2-(2-methoxyethoxy)ethyl>-4-(trans-2-phenylethenyl)thiophen (75997-16-9) + 3-formyl-4-(trans-2-phenylethenyl)thiophen azine (75997-14-7)

Guidance literature:

In 1,2-dimethoxyethane; for 0.666667h; Heating; carbene-derived products instead expected cyclisation product; thienoazepines formation in the similar conditions with other tosylhydrazone sodium salts; diazo-compound intermediacy;

upstream raw materials:

4-[2-phenylethenyl]thiophene-3-carbaldehyde

3-formyl-4-(trans-2-phenylethenyl)thiophen tosylhydrazone sodium salt

4-bromothiophene-3-carboxaldehyde

benzyltriphenylphosphonium bromide

Refernces