α-Chlor-α-Deutero-β,β,β-trifluoraethylbenzol

Base Information

• Chemical Name: α-Chlor-α-Deutero-β,β,β-trifluoraethylbenzol
• CAS No.: 78844-54-9
• Molecular Formula: C₈H₆ClF₃
• Molecular Weight: 195.576
• Mol file: 78844-54-9.mol

Synonyms:α-Chlor-α-Deutero-β,β,β-trifluoraethylbenzol

Chemical Property of α-Chlor-α-Deutero-β,β,β-trifluoraethylbenzol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-Chlor-α-Deutero-β,β,β-trifluoraethylbenzol

There total 7 articles about α-Chlor-α-Deutero-β,β,β-trifluoraethylbenzol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(+/-)-1-deutero-1-phenyl-2,2,2-trifluoroethanol (2793-54-6) → α-Chlor-α-Deutero-β,β,β-trifluoraethylbenzol (78844-54-9)

Guidance literature:

With phosphorus trichloride;

Reference yield:

α-chloro-β,β-difluorostyrene (394-98-9) → α-Chlor-α-Deutero-β,β,β-trifluoraethylbenzol (78844-54-9)

Guidance literature:

With water-d2; cesium fluoride; In N,N-dimethyl-formamide;

DOI:10.1021/ja00346a048

Reference yield:

1-chloro-2,2,2-trifluoroethylbenzene (384-65-6) → α-Chlor-α-Deutero-β,β,β-trifluoraethylbenzol (78844-54-9)

Guidance literature:

With ethyl [2]alcohol; sodium ethanolate; at 35 - 85 ℃; Kinetics; Thermodynamic data; Mechanism; ΔH(excit.); ΔS(excit.); solvent and primary kinetic isotope effect;

DOI:10.1021/ja00346a048

upstream raw materials:

1-chloro-2,2,2-trifluoroethylbenzene

α-chloro-β,β-difluorostyrene

(+/-)-1-deutero-1-phenyl-2,2,2-trifluoroethanol

α-Chlor-α-Tritio-β,β,β-trifluoraethylbenzol

Downstream raw materials:

1-chloro-2,2,2-trifluoroethylbenzene

α-chloro-β,β-difluorostyrene

1,1,1-trifluoro-2-phenylethane-2,2-d₂

Refernces

• 1、 Dneprovskii, A. S.,Eliseenkov, E. V.,Mil'tsov, S. A.. "MECHANISMS OF FREE-RADICAL REACTIONS. XIII. MECHANISM AND SELECTIVITY OF THE FREE-RADICAL HALOGENATION OF ALKYL AROMATIC HYDROCARBONS WITH FLUOROALKYL SUBSTITUENTS". . p. 317 - 324. Retrieved 2007/10/02.