Edogestrone

Base Information

• Chemical Name: Edogestrone
• CAS No.: 809-01-8
• Molecular Formula: C26H38 O5
• Molecular Weight: 430.585
• Mol file: 809-01-8.mol

Synonyms:Pregn-5-ene-3,20-dione,17-hydroxy-6-methyl-, cyclic 3-(ethylene acetal), acetate (7CI,8CI);Spiro[3H-cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolane], pregn-5-ene-3,20-dionederiv.; 3,3-Ethylenedioxy-17-acetoxy-6-methylpregn-5-en-20-one; Edogesterone;Edogestrone; PH 218

Chemical Property of Edogestrone

Chemical Property:

• Vapor Pressure: 7.63E-11mmHg at 25°C
• Melting Point: 185-187 °C(Solv: acetone (67-64-1); ligroine (8032-32-4))
• Boiling Point: 518.2°C at 760 mmHg
• Flash Point: 247.9°C
• PSA: 61.83000
• Density: 1.16g/cm³
• LogP: 4.97330

Purity/Quality:

EDOGESTRONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Edogestrone

There total 3 articles about Edogestrone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

17α-Acetoxy-6-methyl-Δ5-pregnen-3,20-dion (14994-27-5) + ethylene glycol (107-21-1) → 3-cycloethylenedioxy-6-methyl-17α-acetoxy-pregn-5-ene-20-one (809-01-8)

Guidance literature:

With toluene-4-sulfonic acid; orthoformic acid triethyl ester; at 40 ℃; for 72h;

DOI:10.1080/00397919508011371

Reference yield:

→ 3-cycloethylenedioxy-6-methyl-17α-acetoxy-pregn-5-ene-20-one (809-01-8)

Guidance literature:

17-Acetoxy-6-methyl-pregn-5-en-3,20-dion, Ethylenglykol/Benzol, p-Toluolsulfonsaeure (Siedetemp., Wasserentfernung);

DOI:10.1021/jm00336a030

Reference yield:

→ C26H38O5 (809-01-8)

Guidance literature:

aus dem entspr. Keton mit (CH2OH)2;

upstream raw materials:

17α-Acetoxy-6-methyl-Δ⁵-pregnen-3,20-dion

ethylene glycol

Downstream raw materials:

Medroxyprogesterone acetate

Refernces

• 1、 WEISS,POLETTO,ALLEN Jr.,SCHAUB,RINGLER. "THE ORAL PROGESTATIONAL ACTIVITY OF THE 3-KETALS OF CERTAIN 17-ACETOXY-". . p. 804 - 806. Retrieved 2007/10/10.