4'-hydroxy-2,2-diphenylacetophenone

Base Information

• Chemical Name: 4'-hydroxy-2,2-diphenylacetophenone
• CAS No.: 4873-38-5
• Molecular Formula: C₂₀H₁₆O₂
• Molecular Weight: 288.346
• Mol file: 4873-38-5.mol

Synonyms:4'-hydroxy-2,2-diphenylacetophenone

Chemical Property of 4'-hydroxy-2,2-diphenylacetophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-hydroxy-2,2-diphenylacetophenone

There total 4 articles about 4'-hydroxy-2,2-diphenylacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-1-(4-methoxy-phenyl)-2-phenyl-ethanone (1889-77-6) → 1-(4-methoxyphenyl)-2,2-diphenylethanone (1889-74-3) + 4'-hydroxy-2,2-diphenylacetophenone (4873-38-5)

Guidance literature:

With aluminium trichloride; benzene;

DOI:10.1021/ja01611a093

Reference yield:

ethanol (64-17-5) + 1-bromo-1-(p-methoxyphenyl)-2,2-diphenylethene (25354-48-7) → 1-(4-methoxyphenyl)-2,2-diphenylethanone (1889-74-3) + 4'-hydroxy-2,2-diphenylacetophenone (4873-38-5) + 1-bromo-1-(p-ethoxyphenyl)-2,2-diphenylethene (121410-90-0) + 4'-ethoxy-2,2-diphenylacetophenone (128191-31-1)

Guidance literature:

With hydrogenchloride; sodium hydroxide; Yield given. Multistep reaction; 1.) 120 deg C, 65 h, 2.) reflux, 2 h;

DOI:10.1021/ja00019a025

Reference yield:

diphenylacetic acid chloride (1871-76-7) + phenol (108-95-2,27073-41-2) → 4'-hydroxy-2,2-diphenylacetophenone (4873-38-5)

Guidance literature:

With aluminium trichloride; In nitrobenzene;

upstream raw materials:

2-bromo-1-(4-methoxy-phenyl)-2-phenyl-ethanone

ethanol

1-bromo-1-(p-methoxyphenyl)-2,2-diphenylethene

diphenylacetic acid chloride

Downstream raw materials:

1-(4-Hydroxy-phenyl)-2,2-diphenyl-propan-1-one

1-[4-(2-Diethylamino-ethoxy)-phenyl]-2,2-diphenyl-propan-1-one

1-(4-Benzyloxy-phenyl)-2,2-diphenyl-propan-1-one

1-Benzyloxy-4-(1-methoxy-2,2-diphenyl-vinyl)-benzene

Refernces