Technology Process of N-(3-Formyl-8-methylquinolin-7-yl)-4-[(2R)-tetrahydrofuran-2-ylmethoxy]benzamide
There total 8 articles about N-(3-Formyl-8-methylquinolin-7-yl)-4-[(2R)-tetrahydrofuran-2-ylmethoxy]benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C19H22N2O3; 2-dimethylaminomethylene-1,3-bis(dimethylimmonio)propane bistetrafluoroborate;
With
morpholine;
In
butan-1-ol;
at 80 ℃;
for 14h;
With
water; acetic acid;
In
water;
at 20 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: toluene; hexane; methanol / 0.5 h / 0 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C
2.2: 2 h / 0 - 20 °C
3.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 2 h / 0 - 20 °C
4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 80 °C
4.2: 0 °C
5.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 3 h / 20 °C
6.1: triethylamine / ISOPROPYLAMIDE / 24 h / 20 °C / Cooling with ice
7.1: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 4 h / 20 °C
8.1: morpholine / butan-1-ol / 14 h / 80 °C
8.2: 4 h / 20 °C
With
morpholine; lithium aluminium tetrahydride; oxalyl dichloride; water; hydrogen; triethylamine; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate;
palladium on activated charcoal; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; hexane; ISOPROPYLAMIDE; toluene; butan-1-ol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 2 h / 0 - 20 °C
2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 80 °C
2.2: 0 °C
3.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 3 h / 20 °C
4.1: triethylamine / ISOPROPYLAMIDE / 24 h / 20 °C / Cooling with ice
5.1: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 4 h / 20 °C
6.1: morpholine / butan-1-ol / 14 h / 80 °C
6.2: 4 h / 20 °C
With
morpholine; oxalyl dichloride; water; hydrogen; triethylamine; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate;
palladium on activated charcoal; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; ISOPROPYLAMIDE; toluene; butan-1-ol;