3-methoxypentanedioic acid

Base Information

• Chemical Name: 3-methoxypentanedioic acid
• CAS No.: 152294-13-8
• Molecular Formula: C₆H₁₀O₅
• Molecular Weight: 162.142
• Mol file: 152294-13-8.mol

Synonyms:2-methoxypropane-1,3-dicarboxylic acid

Chemical Property of 3-methoxypentanedioic acid

Chemical Property:

• Vapor Pressure: 0.000134mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methoxypentanedioic acid

There total 5 articles about 3-methoxypentanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.5%

α,α-dibromomethyl methyl ether (3492-44-2) + malonic acid dimethyl ester (108-59-8) → 2-methoxypropane-1,3-dicarboxylic acid (152294-13-8)

Guidance literature:

malonic acid dimethyl ester; With sodium methylate; In methanol; at 70 ℃; for 1h; Large scale;

α,α-dibromomethyl methyl ether; In methanol; for 2h; Reflux; Large scale;

With hydrogenchloride; In water; at 0 - 90 ℃; for 3h; Large scale;

Reference yield: 75.0%

dimethyl 3-methoxyglutaric acid (4126-54-9) → 2-methoxypropane-1,3-dicarboxylic acid (152294-13-8)

Guidance literature:

With sodium hydroxide; In methanol; water; for 20h; Ambient temperature;

Reference yield:

dimethyl 3-hydroxypentanedioate (7250-55-7) → 2-methoxypropane-1,3-dicarboxylic acid (152294-13-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / Ag₂O / dimethylformamide / 48 h / Ambient temperature

2: 75 percent / NaOH / methanol; H₂O / 20 h / Ambient temperature

With sodium hydroxide; silver(l) oxide; In methanol; water; N,N-dimethyl-formamide;

upstream raw materials:

dimethyl 3-methoxyglutaric acid

dimethyl 3-hydroxypentanedioate

α,α-dibromomethyl methyl ether

malonic acid dimethyl ester

Downstream raw materials:

3-methoxypentanedioic acid

acetonedicarboxylic acid

Refernces

• 1、 Yamamoto, Yukio,Iwasa, Mineyuki,Sawada, Seiji,Oda, Jun'ichi. "Asymmetric Synthesis of Optically Active 3-Substituted δ-Valerolactones Using Lipase in Organic Solvents". . p. 3269 - 3274. Retrieved 2007/10/02.