2-Hydroxy-3-methylpyridine

Base Information

• Chemical Name: 2-Hydroxy-3-methylpyridine
• CAS No.: 1003-56-1
• Molecular Formula: C6H7NO
• Molecular Weight: 109.128
• Hs Code.: 29333995
• European Community (EC) Number: 213-710-2
• NSC Number: 4343
• UNII: VM19FN4HHV
• DSSTox Substance ID: DTXSID50143118
• Nikkaji Number: J110.367I
• Wikidata: Q27291896
• ChEMBL ID: CHEMBL4548076
• Mol file: 1003-56-1.mol

Synonyms:3-methyl-2-pyridone

Chemical Property of 2-Hydroxy-3-methylpyridine

Chemical Property:

• Appearance/Colour: Light yellow needles
• Vapor Pressure: 0.000724mmHg at 25°C
• Melting Point: 139-141 °C
• Refractive Index: 1.499
• Boiling Point: 307.4 °C at 760 mmHg
• PKA: 12.61±0.10(Predicted)
• Flash Point: 172.7 °C
• PSA: 32.86000
• Density: 1.053 g/cm³
• LogP: 0.68330
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Soluble in methanol.
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 109.052763847
• Heavy Atom Count: 8
• Complexity: 167

Purity/Quality:

99% ^*data from raw suppliers

3-Methylpyridin-2-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xn,Xi
• Statements: 36/37/38-20/21/22-41-37/38-22
• Safety Statements: 36/37/39-26-22-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=CC=CNC1=O
• Uses: 3-Methyl-2-pyridone, is used as a reactant with chloro-methoxy-methane to produce 1-methoxymethyl-3-methyl-1H-pyridin-2-one. This reaction will need reagent solvent CH2Cl2. The reaction time is 24 hours with ambient temperature

Technology Process of 2-Hydroxy-3-methylpyridine

There total 18 articles about 2-Hydroxy-3-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-methylpyridin-2-ylamine (1603-40-3) → 3-methylpyridin-2-ol (1003-56-1,91914-04-4)

Guidance literature:

With sulfuric acid; sodium carbonate; sodium nitrite; In ethanol; water;

Reference yield: 85.0%

2-Pyridone (142-08-5,1199357-22-6) + bis(1-methyl-1-phenylethyl)peroxide (80-43-3) → 3-Methyl-1H-pyridin-2-one (1003-56-1)

Guidance literature:

With acetic acid; at 120 ℃;

Reference yield: 71.0%

(5-methyl-pyridin-2-yl)amine (1603-41-4) → 5-methyl-pyridin-2-ol (1003-68-5,91914-06-6) + 3-methylpyridin-2-ol (1003-56-1,91914-04-4)

Guidance literature:

upstream raw materials:

3-methylpyridin-2-ylamine

3-methylpyridin-2-yl acetate

hydrogenchloride

2-fluoro-3-methylpyridine

Downstream raw materials:

2 chloro-3-methylpyridine

3-methyl-5-trityl-pyridin-2-ol

5-(biphenyl-4-yl-diphenyl-methyl)-3-methyl-pyridin-2-ol

2-bromo-3-picoline

Refernces

• 1、 Bradlow,Vanderwerf. "-". . p. 509,513. Retrieved 1949.
• 2、 Clark, H. R.,Beth, L. D.,Burton, R. M.,Garrett, D. L.,Miller, A. L.,Muscio, O. J.. "Kinetic Study of the Acid-Promoted Hydrolysis of Some Representative 2-Fluoro Nitrogen Heterocycles". . p. 4363 - 4369. Retrieved 1981.
• 3、 Hirai, Koichi,Iwano, Yuji,Mikoshiba, Isamu,Koyama, Hiroo,Nishi, Takahide. "VERSATILE SYNTHESIS OF AN INTERMEDIATE FOR THE 1β-METHYLCARBAPENEM SYNTHESIS". . p. 277 - 280. Retrieved 1994.
• 4、 Wysocki, Jedrzej,Schlepphorst, Christoph,Glorius, Frank. "Asymmetric Homogeneous Hydrogenation of 2-Pyridones". supporting information. p. 1557 - 1562. Retrieved 2015/06/30.
• 5、 -. "(Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors". . . Retrieved 2008/06/13.