1,2,4-trichloro-3,5-difluoronitrobenzene

Base Information

• Chemical Name: 1,2,4-trichloro-3,5-difluoronitrobenzene
• CAS No.: 136272-33-8
• Molecular Formula: C₆Cl₃F₂NO₂
• Molecular Weight: 262.427
• Mol file: 136272-33-8.mol

Synonyms:1,2,4-trichloro-3,5-difluoronitrobenzene

Chemical Property of 1,2,4-trichloro-3,5-difluoronitrobenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,4-trichloro-3,5-difluoronitrobenzene

There total 2 articles about 1,2,4-trichloro-3,5-difluoronitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-chloro-3,5-difluorobenzene (1435-43-4) → 3,4,5-trichloro-2,6-difluoronitrobenzene (136272-32-7) + 1,2,4-trichloro-3,5-difluoronitrobenzene (136272-33-8)

Guidance literature:

With sulfuric acid; nitric acid; chlorine; aluminium trichloride; Yield given. Multistep reaction. Yields of byproduct given; 1) CH₂Cl₂, 3 deg C, 2) room temp., 1.5 h;

DOI:10.1016/S0022-1139(00)80345-0

Reference yield:

1,3,5-trichlorobenzene (108-70-3,63697-19-8) → 1,2,4-trichloro-3,5-difluoronitrobenzene (136272-33-8)

Guidance literature:

Multi-step reaction with 2 steps

1: KF / various solvent(s) / 12 h / 300 °C

2: 1) Cl₂, 2) conc. H₂SO₄, conc. HNO₃ / 1) CH₂Cl₂, 3 deg C, 2) room temp., 1.5 h

With potassium fluoride; sulfuric acid; nitric acid; chlorine; In various solvent(s);

DOI:10.1016/S0022-1139(00)80345-0

Reference yield:

difluorodichlorobenzene (36556-39-5) + 1-chloro-3,5-difluorobenzene (1435-43-4) + 3,4,5-trichloro-2,6-difluoronitrobenzene (136272-32-7) + 1,2,4-trichloro-3,5-difluoronitrobenzene (136272-33-8) → 2,3-difluoroanilline (4519-40-8)

Guidance literature:

With sulfuric acid; nitric acid; sodium acetate; chlorine; aluminium trichloride; palladium on charcoal; In methanol; dichloromethane;

upstream raw materials:

1-chloro-3,5-difluorobenzene

1,3,5-trichlorobenzene

Downstream raw materials:

2,3-difluoroanilline

Refernces