ethyl 2-methyl-2-phenylselanylbutanoate

Base Information

• Chemical Name: ethyl 2-methyl-2-phenylselanylbutanoate
• CAS No.: 308335-56-0
• Molecular Formula: C₁₃H₁₈O₂Se
• Molecular Weight: 285.245
• Mol file: 308335-56-0.mol

Synonyms:ethyl 2-methyl-2-phenylselanylbutanoate

Chemical Property of ethyl 2-methyl-2-phenylselanylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-methyl-2-phenylselanylbutanoate

There total 6 articles about ethyl 2-methyl-2-phenylselanylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

ethyl 2-cyano-2-methylbutanoate (26739-87-7) + Phenylselenyl bromide (34837-55-3) → ethyl 2-methyl-2-phenylselanylbutanoate (308335-56-0)

Guidance literature:

ethyl 2-cyano-2-methylbutanoate; With naphthalen-1-yl-lithium; In tetrahydrofuran; at -45 ℃; for 0.416667h;

Phenylselenyl bromide; In tetrahydrofuran; at -45 ℃; for 0.25h; Further stages.;

DOI:10.1055/s-2007-990884

Reference yield: 72.0%

ethyl 2-methylbutyrate (7452-79-1,53956-13-1) + Phenylselenyl bromide (34837-55-3) → ethyl 2-methyl-2-phenylselanylbutanoate (308335-56-0)

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

DOI:10.1016/S0040-4020(00)00647-5

Reference yield: 71.0%

Ethyl 2-methyl-2-(phenylseleno)propionate (76893-72-6) + ethyl iodide (75-03-6) → ethyl 2-methyl-2-phenylselanylbutanoate (308335-56-0)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydride; In tetrahydrofuran; at -35 - 20 ℃;

DOI:10.1016/S0040-4020(00)00647-5

upstream raw materials:

ethyl 2-methylbutyrate

Phenylselenyl bromide

Ethyl 2-methyl-2-(phenylseleno)propionate

ethyl iodide

Downstream raw materials:

Ethyl tiglate

ethyl 2-methylenebutyrate

Refernces

• 1、 Lebarillier, Loic,Outurquin, Francis,Paulmier, Claude. "Preparation and oxidation of α-phenylselanyl esters". . p. 7483 - 7493. Retrieved 2007/10/03.