Thieno[3,2-c]pyridine

Base Information

• Chemical Name: Thieno[3,2-c]pyridine
• CAS No.: 272-14-0
• Molecular Formula: C7H5NS
• Molecular Weight: 135.189
• Hs Code.: 2934999090
• European Community (EC) Number: 205-984-7
• UNII: 7F0Y9D444I
• DSSTox Substance ID: DTXSID20181663
• Nikkaji Number: J119.536K
• Wikidata: Q27268176
• Mol file: 272-14-0.mol

Synonyms:Thieno[3,2-c]pyridine;272-14-0;5-Azathianaphthene;Thieno(3,2-c)pyridine;EINECS 205-984-7;UNII-7F0Y9D444I;7F0Y9D444I;thieno[3,2-c]pyridin;SCHEMBL88594;DTXSID20181663;AMY10720;BCP25920;CS-D0447;MFCD01760493;AKOS006238084;DS-1006;PS-4739;LS-152395;FT-0675157;EN300-54451;AI-942/25034343;J-016695;J-524938;Q27268176;Z810507710;TICLOPIDINE HYDROCHLORIDE IMPURITY A [EP IMPURITY];thieno[3,2-c]pyridine Thieno[3,2-c]pyridine (6CI,8CI,9CI) 5-Azathianaphthene 5-Aza-1-benzothiophene, 5-Azabenzo[b]thiophene

Chemical Property of Thieno[3,2-c]pyridine

Chemical Property:

• Vapor Pressure: 0.0266mmHg at 25°C
• Melting Point: 47-49℃
• Refractive Index: 1.689
• Boiling Point: 255.1 °C at 760 mmHg
• PKA: 4.83±0.30(Predicted)
• Flash Point: 112.3 °C
• PSA: 41.13000
• Density: 1.272 g/cm³
• LogP: 2.29630
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: Chloroform, Acetone
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 135.01427034
• Heavy Atom Count: 9
• Complexity: 105

Purity/Quality:

98%,99%, ^*data from raw suppliers

Thieno[3,2-c]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=CC2=C1SC=C2
• Uses: An intermediate of Ticlopidine An intermediate of Ticlopidine (T438325). Thieno[3,2-c]pyridine derivatives are used for treatment of inflammatory disorders.

Technology Process of Thieno[3,2-c]pyridine

There total 23 articles about Thieno[3,2-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

7-methoxy-4,5,6,7-tetrahydro-thieno(3,2-c)pyridine hydrochloride (61962-72-9) + p-toluenesulfonyl chloride (98-59-9) → thieno[3,2-c]pyridine (272-14-0)

Guidance literature:

With potassium carbonate; In dichloromethane; water;

Reference yield: 84.42%

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride (28783-41-7) → thieno[3,2-c]pyridine (272-14-0)

Guidance literature:

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride; With water; sodium hydroxide; In dichloromethane; at 20 ℃;

With manganese(IV) oxide; In toluene; at 140 ℃; for 24h;

Reference yield: 70.0%

C7H7NOS (41056-88-6) → thieno[3,2-c]pyridine (272-14-0)

Guidance literature:

In decalin; at 200 ℃;

DOI:10.1021/jo00199a054

upstream raw materials:

5-(2-chloro-benzyl)-thieno[3,2-c]pyridinium; bromide

thieno[3,2-c]pyridine-6-carboxylic acid

N-(2,2-dimethoxyethyl)-4-methyl-N-3-(thienylmethyl)benzenesulfonamide

C₇H₇NOS

Downstream raw materials:

5-(3-methyl-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine

5-(3,5-dimethoxy-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine

5-(2-methyl-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine

5-(3,4-dichloro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine

Refernces

• 1、 -. "Preparation method of thienopyridine-type ionic rod-like liquid crystal and ionic liquid compound". Paragraph 0041; 0042. . Retrieved 2019/08/18.
• 2、 Zhang, Jingyu,Chen, Shiya,Chen, Fangfang,Xu, Wensheng,Deng, Guo-Jun,Gong, Hang. "Dehydrogenation of Nitrogen Heterocycles Using Graphene Oxide as a Versatile Metal-Free Catalyst under Air". supporting information. p. 2358 - 2363. Retrieved 2017/07/22.