3-(4-chlorophenyl)-2-phenylpropanenitrile

Base Information

• Chemical Name: 3-(4-chlorophenyl)-2-phenylpropanenitrile
• CAS No.: 32970-79-9
• Molecular Formula: C15H12 Cl N
• Molecular Weight: 241.72
• Mol file: 32970-79-9.mol

Synonyms:Propionitrile,3-(p-chlorophenyl)-2-phenyl- (6CI,7CI); NSC 287561

Chemical Property of 3-(4-chlorophenyl)-2-phenylpropanenitrile

Chemical Property:

• Vapor Pressure: 2.32E-05mmHg at 25°C
• Boiling Point: 359.8°C at 760 mmHg
• Flash Point: 142.4°C
• Density: 1.176g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-chlorophenyl)-2-phenylpropanenitrile

There total 8 articles about 3-(4-chlorophenyl)-2-phenylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

phenylacetonitrile (140-29-4) + para-Chlorobenzyl alcohol (873-76-7) → 3-(4-chlorophenyl)-2-phenylpropanenitrile (32970-79-9)

Guidance literature:

With [(bis(2-dicyclohexylphosphinoethyl)amine)Fe(CO)Br₂]; sodium triethylborohydride; sodium hydroxide; In toluene; at 130 ℃; for 6h; Glovebox; Sealed tube; Inert atmosphere; Flow reactor; High pressure;

DOI:10.1002/chem.201803762

Reference yield: 90.0%

(Z)-3-(4-chlorophenyl)-2-phenylacrylonitrile (3695-92-9,70528-19-7,37629-64-4) → 3-(4-chlorophenyl)-2-phenylpropanenitrile (32970-79-9)

Guidance literature:

With sodium tetrahydroborate; In N,N-dimethyl-formamide; Ambient temperature; overnight;

DOI:10.1021/jo01289a038

Reference yield: 54.0%

4-Bromophenylacetonitrile (16532-79-9) + para-Chlorobenzyl alcohol (873-76-7) → 3-(4-chlorophenyl)-2-phenylpropanenitrile (32970-79-9)

Guidance literature:

With C₄₉H₃₈Cl₂N₅O₄PRuS; potassium hydroxide; In toluene; at 140 ℃; for 4h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.organomet.9b00146

upstream raw materials:

4-Chloro-α-phenylcinnamonitrile

benzyl alcohol

phenylacetonitrile

1-Chloro-4-(chloromethyl)benzene

Downstream raw materials:

C₂₆H₂₁ClN₂O₂

2-Phenyl-6-chlor-indanon-⁽¹⁾

(±)-3-(4-chlorophenyl)-2-phenylpropanoic acid

Refernces

• 1、 Arslan, Burcu,Gülcemal, Süleyman. "α-Alkylation of arylacetonitriles with primary alcohols catalyzed by backbone modified N-heterocyclic carbene iridium(i) complexes". . p. 1788 - 1796. Retrieved 2021/02/16.
• 2、 Banerjee, Debasis,Bera, Atanu,Bera, Sourajit. "Nickel-catalyzed hydrogen-borrowing strategy: Chemo-selective alkylation of nitriles with alcohols". supporting information. p. 6850 - 6853. Retrieved 2020/07/04.