4-benzyloxy-3-nitroacetanilide

Base Information

• Chemical Name: 4-benzyloxy-3-nitroacetanilide
• CAS No.: 1223466-35-0
• Molecular Formula: C₁₅H₁₄N₂O₄
• Molecular Weight: 286.287
• Mol file: 1223466-35-0.mol

Synonyms:4-benzyloxy-3-nitroacetanilide

Chemical Property of 4-benzyloxy-3-nitroacetanilide

Chemical Property:

Purity/Quality:

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Technology Process of 4-benzyloxy-3-nitroacetanilide

There total 1 articles about 4-benzyloxy-3-nitroacetanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-(4-hydroxy-3-nitrophenyl)acetamide (51288-37-0) + benzyl bromide (100-39-0) → 4-benzyloxy-3-nitroacetanilide (1223466-35-0)

Guidance literature:

With potassium carbonate; In acetone; at 65 ℃; for 6h; Inert atmosphere;

DOI:10.1039/b924619c

Reference yield: 83.0%

4-benzyloxy-3-nitroacetanilide (1223466-35-0) → 4-benzyloxy-3-nitrobenzenediazonium tetrafluoroborate

Guidance literature:

4-benzyloxy-3-nitroacetanilide; With boron trifluoride methanol complex; In methanol; at 65 ℃; Inert atmosphere;

With tert.-butylnitrite; In methanol; at -15 ℃; for 1.25h; Inert atmosphere;

DOI:10.1039/b924619c

Reference yield:

4-benzyloxy-3-nitroacetanilide (1223466-35-0) → 4-benzyloxy-3-nitro-aniline (99103-38-5)

Guidance literature:

With hydrogenchloride; water; In methanol; for 5h; Reflux; Inert atmosphere;

DOI:10.1039/b924619c

upstream raw materials:

N-(4-hydroxy-3-nitrophenyl)acetamide

benzyl bromide

Downstream raw materials:

4-benzyloxy-3-nitro-aniline

Refernces